Isa Ozbay1,2, Ali Cemal Yumusakhuylu2,3, Rishabh Sethia4, Lai Wei5, Matthew Old2, Amit Agrawal2, Theodoros Teknos2, Enver Ozer2. 1. Department of Otolaryngology, Dumlupinar University, Kutahya, Turkey. 2. Department of Otolaryngology - Head and Neck Surgery, "Arthur G. James" Cancer Hospital and "Richard J. Solove" Research Institute, Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, Ohio. 3. Department of Otolaryngology, Marmara University, Istanbul, Turkey. 4. College of Medicine, The Ohio State University, Columbus, Ohio. 5. Department of Biomedical, The Ohio State University, Columbus, Ohio.
Abstract
BACKGROUND: The purpose of this study was to assess the quality of life (QOL) outcomes in patients who underwent transoral robotic surgery (TORS) for carcinoma of unknown primary (CUP). METHODS: Twenty-nine patients with CUP were administered the Head and Neck Cancer Inventory (HNCI) prospectively to evaluate QOL preoperatively and postoperatively. RESULTS: There was statistically and clinically significant deterioration in 2 of 4 domains (eating and social disruption) in the immediate aftermath of TORS. There was statistically and clinically meaningful deterioration in all 4 domains at 3 months relative to baseline, and there remained statistically and clinically meaningful deterioration in 2 of 4 domains at 6 months compared to baseline. These 2 domains remained statistically and clinically worse than baseline at 12 months. Speech and aesthetics domain scores were comparable at baseline and 12 months. CONCLUSION: Patients reported difficulties with eating and social disruption over the course of 1 year, but problems with speech and appearance abated.
BACKGROUND: The purpose of this study was to assess the quality of life (QOL) outcomes in patients who underwent transoral robotic surgery (TORS) for carcinoma of unknown primary (CUP). METHODS: Twenty-nine patients with CUP were administered the Head and Neck Cancer Inventory (HNCI) prospectively to evaluate QOL preoperatively and postoperatively. RESULTS: There was statistically and clinically significant deterioration in 2 of 4 domains (eating and social disruption) in the immediate aftermath of TORS. There was statistically and clinically meaningful deterioration in all 4 domains at 3 months relative to baseline, and there remained statistically and clinically meaningful deterioration in 2 of 4 domains at 6 months compared to baseline. These 2 domains remained statistically and clinically worse than baseline at 12 months. Speech and aesthetics domain scores were comparable at baseline and 12 months. CONCLUSION:Patients reported difficulties with eating and social disruption over the course of 1 year, but problems with speech and appearance abated.