Literature DB >> 28513300

S100A11 regulates renal carcinoma cell proliferation, invasion, and migration via the EGFR/Akt signaling pathway and E-cadherin.

Lin Liu1,2, Long Miao1, Yang Liu3, Aihua Qi2, Ping Xie4, Jiacun Chen3, Haitao Zhu3.   

Abstract

S100A11 is a S100 protein family member that contributes to cancer progression. Upregulated in human renal cancer tissues, S100A11 may be a prognostic marker for clear cell renal cell carcinoma, but how it functions in cancer is uncertain. Thus, we studied S100A11 and noted knockdown of S100A11 using short hairpin RNA, which inhibited proliferation, invasion, and migration of renal carcinoma cells as well as increased expression of E-cadherin and decreased expression of epidermal growth factor receptor/Akt in renal carcinoma cells. Therefore, S100A11 may be a key molecular target for treating renal carcinoma.

Entities:  

Keywords:  S100A11; epidermal growth factor receptor/Akt; renal carcinoma

Mesh：

Substances：

Year:  2017        PMID： 28513300     DOI： 10.1177/1010428317705337

Source DB:  PubMed          Journal:  Tumour Biol        ISSN： 1010-4283


  7 in total

1.  Correlation between S100A11 and the TGF-β1/SMAD4 pathway and its effects on the proliferation and apoptosis of pancreatic cancer cell line PANC-1.

Authors:  Yi-Fei Ji; Tao Li; Feng Jiang; Wen-Kai Ni; Cheng-Qi Guan; Zhao-Xiu Liu; Cui-Hua Lu; Run-Zhou Ni; Wei Wu; Ming-Bing Xiao
Journal:  Mol Cell Biochem       Date:  2018-06-19       Impact factor: 3.396

2.  VHL-HIF-2α axis-induced SMYD3 upregulation drives renal cell carcinoma progression via direct trans-activation of EGFR.

Authors:  Cheng Liu; Li Liu; Kun Wang; Xiao-Feng Li; Li-Yuan Ge; Run-Zhuo Ma; Yi-Dong Fan; Lu-Chao Li; Zheng-Fang Liu; Min Qiu; Yi-Chang Hao; Zhen-Feng Shi; Chuan-You Xia; Klas Strååt; Yi Huang; Lu-Lin Ma; Dawei Xu
Journal:  Oncogene       Date:  2020-04-14       Impact factor: 9.867

3.  S100 Calcium Binding Protein A11 (S100A11) Promotes The Proliferation, Migration And Invasion Of Cervical Cancer Cells, And Activates Wnt/β-Catenin Signaling.

Authors:  Man Meng; Lin Sang; Xiangyu Wang
Journal:  Onco Targets Ther       Date:  2019-10-22       Impact factor: 4.147

4.  TGF-β transactivates EGFR and facilitates breast cancer migration and invasion through canonical Smad3 and ERK/Sp1 signaling pathways.

Authors:  Yuanyuan Zhao; Jing Ma; Yanling Fan; Zhiyong Wang; Ran Tian; Wei Ji; Fei Zhang; Ruifang Niu
Journal:  Mol Oncol       Date:  2018-01-24       Impact factor: 6.603

5.  S100A11 promotes cell proliferation via P38/MAPK signaling pathway in intrahepatic cholangiocarcinoma.

Authors:  Mei-Xia Zhang; Wei Gan; Chu-Yu Jing; Su-Su Zheng; Yong Yi; Juan Zhang; Xin Xu; Jia-Jia Lin; Bo-Heng Zhang; Shuang-Jian Qiu
Journal:  Mol Carcinog       Date:  2018-10-21       Impact factor: 4.784

6.  KIF18A promotes head and neck squamous cell carcinoma invasion and migration via activation of Akt signaling pathway.

Authors:  Guancheng Liu; Gengming Cai; Xiaosong He; Donghai Huang; Gangcai Zhu; Changhan Chen; Xin Zhang
Journal:  Transl Cancer Res       Date:  2019-10       Impact factor: 1.241

7.  RHBDD1 promotes proliferation, migration, invasion and EMT in renal cell carcinoma via the EGFR/AKT signaling pathway.

Authors:  Mingyang Li; Licheng Cai; Xingyuan Wang; Yipeng Yu; Wengang Jian; Guochang Bao; Zhiming Gao; Junsheng Guo; Jian Zhang; Chunsheng Li; Cheng Zhang
Journal:  Mol Med Rep       Date:  2021-09-28       Impact factor: 2.952
  7 in total

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