Huifeng Xu1, Huan Zheng2, Junling Huang2, Yi Shen2, Ming Luo2. 1. a Department of Cardiology , Tongji Hospital of Tongji University , Shanghai , China. 2. b Department of Geriatrics , Tongji Hospital of Tongji University , Shanghai , China.
Abstract
OBJECTIVE: To explore the association between serum homocysteine (Hcy) concentration and T-cell subsets from patients with essential hypertension. PATIENTS AND METHODS: A total of 218 essential hypertension patients were recruited, of which 170 were H-type essential hypertensive and 48 were non-H-type essential hypertensive. H-type essential hypertensive patients were divided into three groups by concentration of serum Hcy. The peripheral blood T-cell subsets (CD3+%, CD4+%, CD8+ T%, CD4+/CD8+) and clinical features including age, sex, serum creatinine, uric acid, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol were recorded and analyzed with T-cell subsets which were counted by fluorescence activated cytometry. RESULTS: Compared with non-H-type hypertensive patients, CD4+ T-cell percentage in peripheral blood was significantly decreased in H-type hypertensive patients. Because of the increase of Hcy level, CD4+ T-cell percentage decreased. Linear regression analysis showed that Hcy level was negatively correlated with CD4+ T-cell percentage; however, it was positively correlated with CD3+ T-cell percentage. CONCLUSION: A direct association between serum Hcy concentrations and T-cell percentage was observed in patients with essential hypertension. This observation indicates that T-cell subsets might play an important role in hypertension.
OBJECTIVE: To explore the association between serum homocysteine (Hcy) concentration and T-cell subsets from patients with essential hypertension. PATIENTS AND METHODS: A total of 218 essential hypertensionpatients were recruited, of which 170 were H-type essential hypertensive and 48 were non-H-type essential hypertensive. H-type essential hypertensivepatients were divided into three groups by concentration of serum Hcy. The peripheral blood T-cell subsets (CD3+%, CD4+%, CD8+ T%, CD4+/CD8+) and clinical features including age, sex, serum creatinine, uric acid, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol were recorded and analyzed with T-cell subsets which were counted by fluorescence activated cytometry. RESULTS: Compared with non-H-type hypertensivepatients, CD4+ T-cell percentage in peripheral blood was significantly decreased in H-type hypertensivepatients. Because of the increase of Hcy level, CD4+ T-cell percentage decreased. Linear regression analysis showed that Hcy level was negatively correlated with CD4+ T-cell percentage; however, it was positively correlated with CD3+ T-cell percentage. CONCLUSION: A direct association between serum Hcy concentrations and T-cell percentage was observed in patients with essential hypertension. This observation indicates that T-cell subsets might play an important role in hypertension.
Entities:
Keywords:
Essential hypertension; T-cell subsets; homocysteine; immune status
Authors: Tan Li; Jiajia Zhu; Qi Fang; Xiaoyu Duan; Mingzhi Zhang; Shanshan Diao; Yun Zhou; Si Yang; Yan Kong; Xiuying Cai Journal: Biomed Res Int Date: 2018-09-09 Impact factor: 3.411