| Literature DB >> 28512032 |
Nguyen Xuan Cuong1, Le Thi Vien2, Le Hoang1, Tran Thi Hong Hanh2, Do Thi Thao3, Nguyen Van Thanh2, Nguyen Hoai Nam2, Do Cong Thung4, Phan Van Kiem2, Chau Van Minh5.
Abstract
Using various chromatographic separation techniques, eight triterpene diglycosides (1-8), including four new compounds namely stichorrenosides A-D (1-4), were isolated from a methanol extract of the Vietnamese sea cucumber S. horrens. Their structures were elucidated based on spectroscopic analyses, including HR ESI MS, 1D and 2D NMR. Their in vitro cytotoxic activity against five human cancer cell lines, Hep-G2 (hepatoma cancer), KB (epidermoid carcinoma), LNCaP (prostate cancer), MCF7 (breast cancer), and SK-Mel2 (melanoma), was evaluated using SRB methods. Stichorrenoside D (4), stichoposide A (5), and 3β-O-[β-d-xylopyranosyl-(1→2)-β-d-xylopyranosyl]-23S-acetoxyholost-7-ene (7) showed strong cytotoxicity on all five tested cancer cell lines, whereas significant effect was observed for stichorrenoside C (3) and stichoposide B (6).Entities:
Keywords: Cytotoxicity; Stichopodidae; Stichopus horrens; Triterpene glycoside
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Year: 2017 PMID： 28512032 DOI： 10.1016/j.bmcl.2017.05.003
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823