| Literature DB >> 28511994 |
Ekaterina A Trifonova1, Vladimir A Zenin2, Nikolai A Nikitin3, Maria S Yurkova2, Ekaterina M Ryabchevskaya3, Egor V Putlyaev3, Ekaterina K Donchenko3, Olga A Kondakova3, Alexey N Fedorov2, Joseph G Atabekov3, Olga V Karpova3.
Abstract
A novel rubella candidate vaccine based on a structurally modified plant virus - spherical particles (SPs) - was developed. SPs generated by the thermal remodelling of the tobacco mosaic virus are promising platforms for the development of vaccines. SPs combine unique properties: biosafety, stability, high immunogenicity and the effective adsorption of antigens. We assembled in vitro and characterised complexes (candidate vaccine) based on SPs and the rubella virus recombinant antigen. The candidate vaccine induced a strong humoral immune response against rubella. The IgG isotypes ratio indicated the predominance of IgG1 which plays a key role in immunity to natural rubella infection. The immune response was generally directed against the rubella antigen within the complexes. We suggest that SPs can act as a platform (depot) for the rubella antigen, enhancing specific immune response. Our results demonstrate that SPs-antigen complexes can be an effective and safe candidate vaccine against rubella.Entities:
Keywords: Adjuvant; Plant virus; Rubella; Spherical particles; Structural modified plant virus; Vaccine
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Year: 2017 PMID： 28511994 DOI： 10.1016/j.antiviral.2017.05.006
Source DB: PubMed Journal: Antiviral Res ISSN： 0166-3542 Impact factor: 5.970