Saurabh Juneja1, Ajit Singh Rathore2, Kanika Sharma3, Devicharan Shetty4, Anshi Jain5. 1. Reader, Department of Oral Pathology, I.T.S. Dental College, Ghaziabad, Uttar Pradesh, India. 2. Professor, Department of Oral Pathology, I.T.S Dental College, Ghaziabad, Uttar Pradesh, India. 3. Postgraduate Student, Department of Oral Pathology, I.T.S. Dental College, Ghaziabad, Uttar Pradesh, India. 4. Professor and Head, Department of Oral Pathology, I.T.S. Dental College, Ghaziabad, Uttar Pradesh, India. 5. Senior Lecturer, Department of Oral Pathology, I.T.S. Dental College, Ghaziabad, Uttar Pradesh, India.
Abstract
INTRODUCTION: Oxidative stress has been implicated in tumourigenesis by affecting the actions of various protein kinases and transcription factors, and resulting in damage to DNA structure by the deamination of nucleotides and the generation of free radicals. Derangements in the antioxidant defence mechanism have been considered in the pathogenesis of oral cancer. AIM: To evaluate and compare the serum levels of nitric oxide and vitamin C in cases of Oral Potentially Malignant Disorders (OPMDs) and Oral Squamous Cell Carcinoma (OSCC) and healthy controls. MATERIALS AND METHODS: Serum from 20 patients with OSCC, 20 patients with OPMDs and 10 healthy subjects were analyzed for levels of nitric oxide and vitamin C using UV spectrophotometry. Antioxidant-Oxidant Index (AOI) was calculated by calculating the ratio between the levels of nitric oxide and vitamin C. RESULTS: The mean nitric oxide levels were elevated in OSCC group, as compared to OPMD and control group, whereas, mean serum vitamin C levels were reduced in OSCC group as compared to OPMDs and control group (statistically significant, p<0.05). There was significant increase in AOI from control group (0.023), OPMDs (0.167) and OSCC group (0.279) (p<0.05). CONCLUSION: Assessment of levels of antioxidant oxidant markers are useful tools in monitoring the progression of OPMDs to OSCC. AOI is an objective tool to assess the oxidative stress in these patients.
INTRODUCTION: Oxidative stress has been implicated in tumourigenesis by affecting the actions of various protein kinases and transcription factors, and resulting in damage to DNA structure by the deamination of nucleotides and the generation of free radicals. Derangements in the antioxidant defence mechanism have been considered in the pathogenesis of oral cancer. AIM: To evaluate and compare the serum levels of nitric oxide and vitamin C in cases of Oral Potentially Malignant Disorders (OPMDs) and Oral Squamous Cell Carcinoma (OSCC) and healthy controls. MATERIALS AND METHODS: Serum from 20 patients with OSCC, 20 patients with OPMDs and 10 healthy subjects were analyzed for levels of nitric oxide and vitamin C using UV spectrophotometry. Antioxidant-Oxidant Index (AOI) was calculated by calculating the ratio between the levels of nitric oxide and vitamin C. RESULTS: The mean nitric oxide levels were elevated in OSCC group, as compared to OPMD and control group, whereas, mean serum vitamin C levels were reduced in OSCC group as compared to OPMDs and control group (statistically significant, p<0.05). There was significant increase in AOI from control group (0.023), OPMDs (0.167) and OSCC group (0.279) (p<0.05). CONCLUSION: Assessment of levels of antioxidant oxidant markers are useful tools in monitoring the progression of OPMDs to OSCC. AOI is an objective tool to assess the oxidative stress in these patients.
Authors: Valeria Edefonti; Mia Hashibe; Maria Parpinel; Federica Turati; Diego Serraino; Keitaro Matsuo; Andrew F Olshan; Jose P Zevallos; Deborah M Winn; Kirsten Moysich; Zuo-Feng Zhang; Hal Morgenstern; Fabio Levi; Karl Kelsey; Michael McClean; Cristina Bosetti; Carlotta Galeone; Stimson Schantz; Guo-Pei Yu; Paolo Boffetta; Yuan-Chin Amy Lee; Shu-Chun Chuang; Carlo La Vecchia; Adriano Decarli Journal: Int J Cancer Date: 2015-01-28 Impact factor: 7.396
Authors: Leonie de Munter; Denise H E Maasland; Piet A van den Brandt; Bernd Kremer; Leo J Schouten Journal: Am J Clin Nutr Date: 2015-07-08 Impact factor: 7.045