| Literature DB >> 28510139 |
E D Nikolskaya1, O A Zhunina2, N G Yabbarov2, V I Shvets3, B I Krugliy2, E S Severin2.
Abstract
A recombinant alpha-fetoprotein (rAFP) was obtained in the yeast P. pastoris system, and its functional activity was confirmed. A method for producing polymer particles loaded with dactinomycin was developed, and a conjugate of these nanoparticles with rAFP was synthesized. The efficiency of the obtained conjugate on the HeLa, SKOV3, and MG-63 tumor cells and the absence of toxicity on the normal cells was shown. Experiments in vivo demonstrated a significant increase in the antitumor efficacy of the conjugate at a lower general toxicity as compared to the commercially available dactinomycin.Entities:
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Year: 2017 PMID： 28510139 DOI： 10.1134/S1607672917020156
Source DB: PubMed Journal: Dokl Biochem Biophys ISSN： 1607-6729 Impact factor: 0.788