Literature DB >> 28510123

Alzheimer's disease Aβ42 peptide induces an increase in Na,K-ATPase glutathionylation.

V A Lakunina1, I Y Petrushanko1, K M Burnysheva1, V A Mitkevich1, A A Makarov2.   

Abstract

We have shown that the inhibition of Na,K-ATPase during its long-term incubation with amyloid beta (Aβ42), an Alzheimer's disease protein, is caused by the change in the thiol redox status of cells leading to induction of glutathionylation α-subunit of Na,K-ATPase. To restore the activity of Na,K-ATPase, it is proposed to use reducing agents, which promote normalization of the redox status of cells and deglutathionylation of the protein.

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Year:  2017        PMID： 28510123     DOI： 10.1134/S1607672917020077

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  12 in total

Review 1.  Protein-thiol oxidation and cell death: regulatory role of glutaredoxins.

Authors:  Erin M G Allen; John J Mieyal
Journal:  Antioxid Redox Signal       Date:  2012-06-05       Impact factor: 8.401

2.  Alterations on Na⁺,K⁺-ATPase and acetylcholinesterase activities induced by amyloid-β peptide in rat brain and GM1 ganglioside neuroprotective action.

Authors:  Fernando Kreutz; Emilene B Scherer; Andréa G K Ferreira; Fernanda Dos Santos Petry; Camila Lino Pereira; Fabiana Santana; Angela Terezinha de Souza Wyse; Christianne Gazzana Salbego; Vera Maria Treis Trindade
Journal:  Neurochem Res       Date:  2013-09-08       Impact factor: 3.996

3.  Na-K-ATPase in rat cerebellar granule cells is redox sensitive.

Authors:  I Petrushanko; N Bogdanov; E Bulygina; B Grenacher; T Leinsoo; A Boldyrev; M Gassmann; A Bogdanova
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2005-11-17       Impact factor: 3.619

4.  The effects of different antioxidants on the activity of cerebrocortical MnSOD and Na,K-ATPase from post mortem Alzheimer's disease and age-matched normal brains.

Authors:  C Kairane; R Mahlapuu; K Ehrlich; M Zilmer; U Soomets
Journal:  Curr Alzheimer Res       Date:  2014-01       Impact factor: 3.498

5.  An increase in S-glutathionylated proteins in the Alzheimer's disease inferior parietal lobule, a proteomics approach.

Authors:  Shelley F Newman; Rukhsana Sultana; Marzia Perluigi; Rafella Coccia; Jian Cai; William M Pierce; Jon B Klein; Delano M Turner; D Allan Butterfield
Journal:  J Neurosci Res       Date:  2007-05-15       Impact factor: 4.164

Review 6.  Na⁺-K⁺-ATPase, a potent neuroprotective modulator against Alzheimer disease.

Authors:  Li-Nan Zhang; Yong-Jun Sun; Shuo Pan; Jun-Xia Li; Yin-E Qu; Yao Li; Yong-Li Wang; Zi-Bin Gao
Journal:  Fundam Clin Pharmacol       Date:  2012-10-03       Impact factor: 2.748

7.  S-glutathionylation of the Na,K-ATPase catalytic α subunit is a determinant of the enzyme redox sensitivity.

Authors:  Irina Yu Petrushanko; Sergej Yakushev; Vladimir A Mitkevich; Yuliya V Kamanina; Rustam H Ziganshin; Xianyu Meng; Anastasiya A Anashkina; Asya Makhro; Olga D Lopina; Max Gassmann; Alexander A Makarov; Anna Bogdanova
Journal:  J Biol Chem       Date:  2012-07-13       Impact factor: 5.157

Review 8.  Dysregulation of glutathione homeostasis in neurodegenerative diseases.

Authors:  William M Johnson; Amy L Wilson-Delfosse; John J Mieyal
Journal:  Nutrients       Date:  2012-10-09       Impact factor: 5.717

9.  Isomerization of Asp7 leads to increased toxic effect of amyloid-β42 on human neuronal cells.

Authors:  V A Mitkevich; I Y Petrushanko; Y E Yegorov; O V Simonenko; K S Vishnyakova; A A Kulikova; P O Tsvetkov; A A Makarov; S A Kozin
Journal:  Cell Death Dis       Date:  2013-11-28       Impact factor: 8.469

10.  Direct interaction of beta-amyloid with Na,K-ATPase as a putative regulator of the enzyme function.

Authors:  Irina Yu Petrushanko; Vladimir A Mitkevich; Anastasia A Anashkina; Alexei A Adzhubei; Ksenia M Burnysheva; Valentina A Lakunina; Yulia V Kamanina; Elena A Dergousova; Olga D Lopina; Omolara O Ogunshola; Anna Yu Bogdanova; Alexander A Makarov
Journal:  Sci Rep       Date:  2016-06-14       Impact factor: 4.379
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  3 in total

Review 1.  The roles of S-nitrosylation and S-glutathionylation in Alzheimer's disease.

Authors:  Ryan R Dyer; Katarena I Ford; Renã A S Robinson
Journal:  Methods Enzymol       Date:  2019       Impact factor: 1.600

2.  Effect of a purine derivative containing selenium to improve memory decline and anxiety through modulation of the cholinergic system and Na+/K+-ATPase in an Alzheimer's disease model.

Authors:  Ethel Antunes Wilhelm; Cristiane Luchese; Mikaela Peglow Pinz; Ane Gabriela Vogt; Karline da Costa Rodrigues; Angélica Schiavom Dos Reis; Luis Fernando Barbosa Duarte; Mariana Gallio Fronza; William Borges Domingues; Eduardo Bierhaus Blodorn; Diego Alves; Vinicius Farias Campos; Lucielli Savegnago
Journal:  Metab Brain Dis       Date:  2021-03-02       Impact factor: 3.584

3.  Na,K-ATPase Acts as a Beta-Amyloid Receptor Triggering Src Kinase Activation.

Authors:  Irina Yu Petrushanko; Artem M Tverskoi; Evgeny P Barykin; Aleksandra V Petrovskaya; Maria A Strelkova; Olga G Leonova; Anastasia A Anashkina; Anna P Tolstova; Alexei A Adzhubei; Anna Yu Bogdanova; Alexander A Makarov; Vladimir A Mitkevich
Journal:  Cells       Date:  2022-09-03       Impact factor: 7.666
  3 in total

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