| Literature DB >> 28509923 |
Ren-Rong Liu1, Lei Zhu, Jiang-Ping Hu, Chuan-Jun Lu, Jian-Rong Gao, Yu Lan, Yi-Xia Jia.
Abstract
Enantioselective alkynylation of cyclic N-sulfonyl α-ketiminoesters with terminal alkynes was developed by using an Ni(ClO4)2/(R)-DTBM-Segphos complex as a catalyst. A range of propargylic amides bearing quaternary stereocenters were afforded in excellent enantioselectivities (up to 97% ee). Theoretical studies revealed that this reaction proceeded via a Friedel-Crafts-type reaction pathway.Entities:
Year: 2017 PMID： 28509923 DOI： 10.1039/c7cc01015j
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222