Literature DB >> 28509552

Amino Acid Conjugated Anthraquinones from the Marine-Derived Fungus Penicillium sp. SCSIO sof101.

Minghe Luo1,2, Zhaomeng Cui3, Hongbo Huang1, Xianqin Song2, Aijun Sun1, Yongjun Dang3, Laichun Lu2, Jianhua Ju1,4.   

Abstract

Emodacidamides A-H (1-8), natural products featuring anthraquinone-amino acid conjugates, have been isolated from a marine-derived fungus, Penicillium sp. SCSIO sof101, together with known anthraquinones 9 and 10. The planar structures of 1-8 were elucidated using a combination of NMR spectroscopy and mass spectrometry. The absolute configurations of the amino acid residues were confirmed using Marfey's method and chiral-phase HPLC analyses. Additionally, isolates were evaluated for possible immunomodulatory and cytotoxic activities. Emodacidamides A (1), C (3), D (4), and E (5) inhibited interleukin-2 secretion from Jurkat cells with IC50 values of 4.1, 5.1, 12, and 5.4 μM, respectively.

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Year:  2017        PMID： 28509552     DOI： 10.1021/acs.jnatprod.7b00269

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  6 in total

Review 1.  Anthraquinones and Their Analogues from Marine-Derived Fungi: Chemistry and Biological Activities.

Authors:  Salar Hafez Ghoran; Fatemeh Taktaz; Seyed Abdulmajid Ayatollahi; Anake Kijjoa
Journal:  Mar Drugs       Date:  2022-07-25       Impact factor: 6.085

2.  White Rot Fungi Produce Novel Tire Wear Compound Metabolites and Reveal Underappreciated Amino Acid Conjugation Pathways.

Authors:  Erica A Wiener; Gregory H LeFevre
Journal:  Environ Sci Technol Lett       Date:  2022-03-18

Review 3.  A Review: Halogenated Compounds from Marine Fungi.

Authors:  Cong Wang; Huanyun Lu; Jianzhou Lan; K H Ahammad Uz Zaman; Shugeng Cao
Journal:  Molecules       Date:  2021-01-16       Impact factor: 4.411

Review 4.  Metabolites of Marine Sediment-Derived Fungi: Actual Trends of Biological Activity Studies.

Authors:  Anton N Yurchenko; Elena V Girich; Ekaterina A Yurchenko
Journal:  Mar Drugs       Date:  2021-02-04       Impact factor: 5.118

5.  Xanthones and anthraquinones from the soil fungus Penicillium sp. DWS10-P-6.

Authors:  Ya-Jing Wang; Nan Ma; Chun-Yue Liu; Yi-Xuan Feng; Feng-Xiang Zhang; Chang Li; Yue-Hu Pei
Journal:  RSC Adv       Date:  2021-01-14       Impact factor: 3.361

Review 6.  Chemical diversity, medicinal potentialities, biosynthesis, and pharmacokinetics of anthraquinones and their congeners derived from marine fungi: a comprehensive update.

Authors:  Mohamed Sebak; Fatma Molham; Claudio Greco; Mohamed A Tammam; Mansour Sobeh; Amr El-Demerdash
Journal:  RSC Adv       Date:  2022-09-01       Impact factor: 4.036
  6 in total

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