Literature DB >> 2850929

Effects of bupivacaine on membrane currents of guinea-pig ventricular myocytes.

J Sánchez-Chapula1.   

Abstract

The effects of bupivacaine on the membrane currents of single guinea-pig ventricular myocytes were investigated using the whole-cell patch-clamp technique. Bupivacaine decreased the inward calcium current in a concentration-dependent way at concentrations of 10 microM and higher. Bupivacaine also decreased the delayed outward current without modifying the inward-rectifying potassium current. From these results it can be concluded that bupivacaine, at concentrations lower than 10 microM, does not exert its negative inotropic effect by decreasing the calcium current. This mechanism may play a role at higher concentrations of the drug.

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Year:  1988        PMID： 2850929     DOI： 10.1016/0014-2999(88)90274-9

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  17 in total

1.  Mechanism underlying bupivacaine inhibition of G protein-gated inwardly rectifying K+ channels.

Authors:  W Zhou; C Arrabit; S Choe; P A Slesinger
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-15       Impact factor: 11.205

2.  Effects of levobupivacaine, ropivacaine and bupivacaine on HERG channels: stereoselective bupivacaine block.

Authors:  Teresa González; Cristina Arias; Ricardo Caballero; Ignacio Moreno; Eva Delpón; Juan Tamargo; Carmen Valenzuela
Journal:  Br J Pharmacol       Date:  2002-12       Impact factor: 8.739

Review 3.  [Toxicology of local anesthetics. Clinical, therapeutic and pathological mechanisms].

Authors:  W Zink; B M Graf
Journal:  Anaesthesist       Date:  2003-12       Impact factor: 1.041

4.  Direct cardiac effects of intracoronary bupivacaine, levobupivacaine and ropivacaine in the sheep.

Authors:  D H Chang; L A Ladd; S Copeland; M A Iglesias; J L Plummer; L E Mather
Journal:  Br J Pharmacol       Date:  2001-02       Impact factor: 8.739

Review 5.  Adverse effects and drug interactions associated with local and regional anaesthesia.

Authors:  M Naguib; M M Magboul; A H Samarkandi; M Attia
Journal:  Drug Saf       Date:  1998-04       Impact factor: 5.606

6.  Effects of a quaternary bupivacaine derivative on delayed rectifier K(+) currents.

Authors:  M Longobardo; T González; R Navarro-Polanco; R Caballero; E Delpón; J Tamargo; D J Snyders; M M Tamkun; C Valenzuela
Journal:  Br J Pharmacol       Date:  2000-05       Impact factor: 8.739

7.  Bupivacaine-induced slow-inward current inhibition: a voltage clamp study on frog atrial fibres.

Authors:  J E de La Coussaye; C Massé; B P Bassoul; J J Eledjam; J P Gagnol; A Sassine
Journal:  Can J Anaesth       Date:  1990-10       Impact factor: 5.063

8.  Effects of imipramine on the transient outward current in rabbit atrial single cells.

Authors:  E Delpón; J Tamargo; J Sánchez-Chapula
Journal:  Br J Pharmacol       Date:  1992-06       Impact factor: 8.739

9.  Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers.

Authors:  C Valenzuela; E Delpón; M M Tamkun; J Tamargo; D J Snyders
Journal:  Biophys J       Date:  1995-08       Impact factor: 4.033

10.  The cholinomimetic agent bethanechol activates IK(ACh) in feline atrial myocytes.

Authors:  Dora E Benavides-Haro; Ricardo A Navarro-Polanco; José A Sánchez-Chapula
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-09-05       Impact factor: 3.000
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