Literature DB >> 28509081

Interleukin-6-Mediated Induced Pluripotent Stem Cell (iPSC)-Derived Neural Differentiation.

Yanuar Alan Sulistio1, Han Kyu Lee1, Sung Jun Jung1, Klaus Heese2.   

Abstract

In an aging society with an increasing threat to higher brain cognitive functions due to dementia, it becomes imperative to identify new molecular remedies for supporting adult neurogenesis. Interleukin-6 (IL-6) is a promising cytokine that can support neurogenesis under conditions of neurodegeneration, and neuron replacement is eventually possible due to its agonistic acting soluble receptor sIL-6R. Here, we report that activation of the IL-6-signal transducer and activator of transcription 3 (STAT3) axis is neurogenic and has potential therapeutic applications for the treatment of neurodegenerative diseases such as Parkinson's disease (PD).

Entities:  

Keywords:  BDNF; Brain; Interleukin-6; Neuron; Neurotrophin; STAT3

Mesh：

Substances：

Year:  2017        PMID： 28509081     DOI： 10.1007/s12035-017-0594-3

Source DB:  PubMed          Journal:  Mol Neurobiol        ISSN： 0893-7648            Impact factor:   5.590


  69 in total

1.  Early sequential formation of functional GABA(A) and glutamatergic synapses on CA1 interneurons of the rat foetal hippocampus.

Authors:  Sonia Hennou; Ilgam Khalilov; Diabé Diabira; Yehezkel Ben-Ari; Henri Gozlan
Journal:  Eur J Neurosci       Date:  2002-07       Impact factor: 3.386

2.  Directly linked soluble IL-6 receptor-IL-6 fusion protein induces astrocyte differentiation from neuroepithelial cells via activation of STAT3.

Authors:  T Takizawa; M Yanagisawa; W Ochiai; K Yasukawa; T Ishiguro; K Nakashima; T Taga
Journal:  Cytokine       Date:  2001-03-07       Impact factor: 3.861

3.  The IL-6/sIL-6R fusion protein hyper-IL-6 promotes neurite outgrowth and neuron survival in cultured enteric neurons.

Authors:  K H Schäfer; P Mestres; P März; S Rose-John
Journal:  J Interferon Cytokine Res       Date:  1999-05       Impact factor: 2.607

4.  Single and local blockade of interleukin-6 signaling promotes neuronal differentiation from transplanted embryonic stem cell-derived neural precursor cells.

Authors:  Masanori Gomi; Tomohiro Aoki; Yasushi Takagi; Masaki Nishimura; Yoshiyuki Ohsugi; Masahiko Mihara; Kazuhiko Nozaki; Nobuo Hashimoto; Susumu Miyamoto; Jun Takahashi
Journal:  J Neurosci Res       Date:  2011-05-06       Impact factor: 4.164

5.  Neurons generated from adult rat hippocampal stem cells form functional glutamatergic and GABAergic synapses in vitro.

Authors:  H Toda; J Takahashi; A Mizoguchi; K Koyano; N Hashimoto
Journal:  Exp Neurol       Date:  2000-09       Impact factor: 5.330

6.  Differentiation of mesencephalic progenitor cells into dopaminergic neurons by cytokines.

Authors:  Z D Ling; E D Potter; J W Lipton; P M Carvey
Journal:  Exp Neurol       Date:  1998-02       Impact factor: 5.330

Review 7.  The glial nature of embryonic and adult neural stem cells.

Authors:  Arnold Kriegstein; Arturo Alvarez-Buylla
Journal:  Annu Rev Neurosci       Date:  2009       Impact factor: 12.449

8.  Accelerated Nerve Regeneration in Mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after trauma.

Authors:  H Hirota; H Kiyama; T Kishimoto; T Taga
Journal:  J Exp Med       Date:  1996-06-01       Impact factor: 14.307

9.  Cell therapies for Parkinson's disease: how far have we come?

Authors:  Thomas B Stoker; Roger A Barker
Journal:  Regen Med       Date:  2016-11-25       Impact factor: 3.806

Review 10.  Induced pluripotent stem cells in Parkinson's disease: scientific and clinical challenges.

Authors:  Bin Xiao; Huck Hui Ng; Ryosuke Takahashi; Eng-King Tan
Journal:  J Neurol Neurosurg Psychiatry       Date:  2016-02-01       Impact factor: 10.154
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  3 in total

1.  A Novel Divergent Gene Transcription Paradigm-the Decisive, Brain-Specific, Neural |-Srgap2-Fam72a-| Master Gene Paradigm.

Authors:  Nguyen Thi Thanh Ho; Arne Kutzner; Klaus Heese
Journal:  Mol Neurobiol       Date:  2019-01-26       Impact factor: 5.590

2.  Interleukin 6 promotes an in vitro mineral deposition by stem cells isolated from human exfoliated deciduous teeth.

Authors:  Nunthawan Nowwarote; Waleerat Sukarawan; Kiattipan Kanjana; Prasit Pavasant; Benjamin P J Fournier; Thanaphum Osathanon
Journal:  R Soc Open Sci       Date:  2018-10-31       Impact factor: 2.963

3.  The preconditioning of lithium promotes mesenchymal stem cell-based therapy for the degenerated intervertebral disc via upregulating cellular ROS.

Authors:  Zemin Zhu; Hongyuan Xing; Ruofu Tang; Shengjun Qian; Shaoqi He; Qiang Hu; Ning Zhang
Journal:  Stem Cell Res Ther       Date:  2021-04-14       Impact factor: 6.832
  3 in total

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