Literature DB >> 28508985

Light chain Fanconi syndrome in a patient with acute myeloid leukemia and monoclonal gammopathy of undetermined significance.

Daniel W Ross1, Rimda Wanchoo2, Adriana Guigova3, Cristina Ghiuzeli3, Steven L Allen3, Kenar D Jhaveri2.   

Abstract

Proximal tubules are a target for paraproteinemic diseases. Cast nephropathy, light chain deposition diseases, and amyloidosis are frequently encountered in patients with multiple myeloma. Rarely, a subset of patients develop light chain Fanconi syndrome (LCFS). LCFS has been reported with multiple myeloma, monoclonal gammopathy of renal significance (MGRS), chronic lymphocytic leukemia, Waldenstrom's macroglobulinemia and diffuse large B-cell lymphoma. No cases have been described with other hematologic malignancies. We report the first case of lambda LCFS in a patient with both acute myeloid leukemia (AML) and monoclonal gammopathy of undetermined significance (MGUS).

Entities:  

Keywords:  Acute myeloid leukemia; Light chain Fanconi syndrome; MGRS; MGUS; Onconephrology

Year:  2016        PMID： 28508985      PMCID： PMC5413759          DOI： 10.1007/s13730-016-0232-3

Source DB:  PubMed          Journal:  CEN Case Rep        ISSN： 2192-4449


  10 in total

Review 1.  Light chain tubulopathy without Fanconi syndrome.

Authors:  Samar M Said; Adel M Assaad; Jorge Cerda; Samih H Nasr
Journal:  Nephrol Dial Transplant       Date:  2006-09-17       Impact factor: 5.992

2.  Proximal tubulopathies associated with monoclonal light chains: the spectrum of clinicopathologic manifestations and molecular pathogenesis.

Authors:  Guillermo A Herrera
Journal:  Arch Pathol Lab Med       Date:  2014-10       Impact factor: 5.534

Review 3.  Light chain deposition disease: novel biological insights and treatment advances.

Authors:  V H Jimenez-Zepeda
Journal:  Int J Lab Hematol       Date:  2012-04-04       Impact factor: 2.877

4.  The morphologic spectrum and clinical significance of light chain proximal tubulopathy with and without crystal formation.

Authors:  Christopher P Larsen; Jane M Bell; Alexis A Harris; Nidia C Messias; Yihan H Wang; Patrick D Walker
Journal:  Mod Pathol       Date:  2011-06-24       Impact factor: 7.842

5.  Prevalence of monoclonal gammopathy of undetermined significance.

Authors:  Robert A Kyle; Terry M Therneau; S Vincent Rajkumar; Dirk R Larson; Matthew F Plevak; Janice R Offord; Angela Dispenzieri; Jerry A Katzmann; L Joseph Melton
Journal:  N Engl J Med       Date:  2006-03-30       Impact factor: 91.245

Review 6.  Adult Fanconi syndrome secondary to light chain gammopathy. Clinicopathologic heterogeneity and unusual features in 11 patients.

Authors:  T Messiaen; S Deret; B Mougenot; F Bridoux; P Dequiedt; J J Dion; R Makdassi; F Meeus; J Pourrat; G Touchard; P Vanhille; P Zaoui; P Aucouturier; P M Ronco
Journal:  Medicine (Baltimore)       Date:  2000-05       Impact factor: 1.889

7.  Reactive plasmacytosis and lymphocytosis in acute myeloid leukemia.

Authors:  N S Rosenthal; D C Farhi
Journal:  Hematol Pathol       Date:  1994

8.  Expanding the pathologic spectrum of immunoglobulin light chain proximal tubulopathy.

Authors:  Umesh Kapur; Kevin Barton; Raoul Fresco; David J Leehey; David J Leehy; Maria M Picken
Journal:  Arch Pathol Lab Med       Date:  2007-09       Impact factor: 5.534

9.  Florid plasmacytosis in a case of acute myeloid leukemia: A diagnostic dilemma.

Authors:  Aruna Rangan; Bhavna Arora; Pooja Rangan; Tina Dadu
Journal:  Indian J Med Paediatr Oncol       Date:  2010-01

10.  Plasmacytosis in acute myeloid leukemia: two cases of plasmacytosis and increased IL-6 production in the AML blast cells.

Authors:  G G Wulf; G Jahns-Streubel; B Hemmerlein; K Bonnekessen; B Wörmann; W Hiddemann
Journal:  Ann Hematol       Date:  1998-06       Impact factor: 3.673
  10 in total

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