Literature DB >> 28508314

TRPC Channels and Alzheimer's Disease.

Rui Lu1, Qian He1, Junfeng Wang2.   

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disease in the world. The "amyloid hypothesis" is one of the predominant hypotheses for the pathogenesis of AD. Besides, tau protein accumulation, calcium homeostasis disruption, and glial cell activation are also remarkable features in AD. Recently, there are some reports showing that TRPC channels may function in AD development, especially TRPC6. In this chapter, we will discuss the evidence for the involvement of TRPC channels in Alzheimer's disease and the potential of therapeutics for AD based on TRPC channels.

Entities:  

Keywords:  Alzheimer’s disease; Calcium; TRPC6; β-amyloid

Mesh：

Substances：

Year:  2017        PMID： 28508314     DOI： 10.1007/978-94-024-1088-4_7

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  7 in total

Review 1.  TRPC channels: Structure, function, regulation and recent advances in small molecular probes.

Authors:  Hongbo Wang; Xiaoding Cheng; Jinbin Tian; Yuling Xiao; Tian Tian; Fuchun Xu; Xuechuan Hong; Michael X Zhu
Journal:  Pharmacol Ther       Date:  2020-01-28       Impact factor: 12.310

2.  Analysis of hyperforin (St. John's wort) action at TRPC6 channel leads to the development of a new class of antidepressant drugs.

Authors:  Yamina El Hamdaoui; Fang Zheng; Nikolas Fritz; Lian Ye; Mai Anh Tran; Kevin Schwickert; Tanja Schirmeister; Albert Braeuning; Dajana Lichtenstein; Ute A Hellmich; Dorothee Weikert; Markus Heinrich; Giulia Treccani; Michael K E Schäfer; Gabriel Nowak; Bernd Nürnberg; Christian Alzheimer; Christian P Müller; Kristina Friedland
Journal:  Mol Psychiatry       Date:  2022-10-12       Impact factor: 13.437

Review 3.  TRP Channels as Emerging Therapeutic Targets for Neurodegenerative Diseases.

Authors:  Chansik Hong; Byeongseok Jeong; Hyung Joon Park; Ji Yeon Chung; Jung Eun Lee; Jinsung Kim; Young-Cheul Shin; Insuk So
Journal:  Front Physiol       Date:  2020-04-15       Impact factor: 4.566

Review 4.  The Role of TRP Channels and PMCA in Brain Disorders: Intracellular Calcium and pH Homeostasis.

Authors:  Sung-Min Hwang; Ji Yeon Lee; Chul-Kyu Park; Yong Ho Kim
Journal:  Front Cell Dev Biol       Date:  2021-01-28

Review 5.  Ion Channel Dysfunction in Astrocytes in Neurodegenerative Diseases.

Authors:  Sijian Wang; Biyao Wang; Dehao Shang; Kaige Zhang; Xu Yan; Xinwen Zhang
Journal:  Front Physiol       Date:  2022-02-09       Impact factor: 4.566

Review 6.  Calmodulin Binding Proteins and Alzheimer's Disease: Biomarkers, Regulatory Enzymes and Receptors That Are Regulated by Calmodulin.

Authors:  Danton H O'Day
Journal:  Int J Mol Sci       Date:  2020-10-05       Impact factor: 5.923

7.  AAV Delivery of shRNA Against TRPC6 in Mouse Hippocampus Impairs Cognitive Function.

Authors:  Ruxin Xie; Zhongke Wang; Tianyao Liu; Rui Xiao; Keyi Lv; Chuan Wu; Yi Luo; Yun Cai; Xiaotang Fan
Journal:  Front Cell Dev Biol       Date:  2021-07-13
  7 in total

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