Literature DB >> 2850808

Smooth muscle cell migration induced by inflammatory cell products and its inhibition by a potent calcium antagonist, nilvadipine.

A Nomoto1, S Mutoh, H Hagihara, I Yamaguchi.   

Abstract

The chemotactic activities of inflammatory cell products for rat aortic smooth muscle cells (SMC) were examined in modified Boyden chambers. A checker board analysis revealed that interleukin-1 (IL-1), leukotriene B4 (LTB4), platelet-derived growth factor (PDGF) and inflammatory exudate from zymosan-activated air pouches stimulated chemotaxis of SMC. The chemotaxis, irrespective of the attractants used, was strongly inhibited by nilvadipine, a potent calcium antagonist, and the IC50 values were around 1 x 10(-10) M. Removal of extracellular calcium abolished the chemotactic activities of the attractants. These results suggest that inflammatory cells such as macrophages and polymorphonuclear leukocytes (PMN) have an important role in the migration of SMC into the intima during atherogenesis, and that nilvadipine might be useful for preventing and treating atherosclerosis.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 2850808     DOI： 10.1016/0021-9150(88)90083-4

Source DB:  PubMed          Journal:  Atherosclerosis        ISSN： 0021-9150            Impact factor:   5.162


  14 in total

1.  Blood polymorphonuclear leukocyte activation in atherosclerosis: effects of aspirin.

Authors:  G Egger; A Burda; A Obernosterer; H Mitterhammer; G Kager; G Jürgens; H P Hofer; J S Fabjan; E Pilger
Journal:  Inflammation       Date:  2001-04       Impact factor: 4.092

2.  Leukotriene B4 signaling through NF-kappaB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia.

Authors:  Magnus Bäck; De-xiu Bu; Robert Bränström; Yuri Sheikine; Zhong-Qun Yan; Göran K Hansson
Journal:  Proc Natl Acad Sci U S A       Date:  2005-11-17       Impact factor: 11.205

3.  Effects of protein tyrosine kinase inhibitors on voltage-operated calcium channel currents in vascular smooth muscle cells and pp60(c-src) kinase activity.

Authors:  S Wijetunge; J S Lymn; A D Hughes
Journal:  Br J Pharmacol       Date:  2000-04       Impact factor: 8.739

4.  Histopathological and ophthalmoscopic evaluation of apocynin on experimental proliferative vitreoretinopathy in rabbit eyes.

Authors:  Murat Atabey Ozer; Nihat Polat; Serkan Ozen; Tevfik Ogurel; Hakan Parlakpinar; Nigar Vardi
Journal:  Int Ophthalmol       Date:  2016-08-05       Impact factor: 2.031

5.  Study on the effect of LncRNA AK094457 on OX-LDL induced vascular smooth muscle cells.

Authors:  Mei Liu; Yiqun Song; Zhongyuan Han
Journal:  Am J Transl Res       Date:  2019-09-15       Impact factor: 4.060

6.  Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis.

Authors:  K Hansen; M Johnell; A Siegbahn; C Rorsman; U Engström; C Wernstedt; C H Heldin; L Rönnstrand
Journal:  EMBO J       Date:  1996-10-01       Impact factor: 11.598

7.  Inhibited proliferation of human umbilical artery smooth muscle cells by xanthinol nicotinate.

Authors:  Xiaodan Bai; Lijun Huang; Kejie Hu; Fujun Qu
Journal:  Med Biol Eng Comput       Date:  2015-12-30       Impact factor: 2.602

8.  Effect of serum withdrawal on the contribution of L-type calcium channels (CaV1.2) to intracellular Ca2+ responses and chemotaxis in cultured human vascular smooth muscle cells.

Authors:  Mahendra K Patel; Gerard F Clunn; Joanne S Lymn; Oneka Austin; Alun D Hughes
Journal:  Br J Pharmacol       Date:  2005-07       Impact factor: 8.739

9.  Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis.

Authors:  Rainer Spanbroek; Rolf Grabner; Katharina Lotzer; Markus Hildner; Anja Urbach; Katharina Ruhling; Michael P W Moos; Brigitte Kaiser; Tina U Cohnert; Thorsten Wahlers; Arthur Zieske; Gabriele Plenz; Horst Robenek; Peter Salbach; Hartmut Kuhn; Olof Radmark; Bengt Samuelsson; Andreas J R Habenicht
Journal:  Proc Natl Acad Sci U S A       Date:  2003-01-27       Impact factor: 11.205

Review 10.  Inflammatory cytokines in vascular dysfunction and vascular disease.

Authors:  Alexander H Sprague; Raouf A Khalil
Journal:  Biochem Pharmacol       Date:  2009-05-04       Impact factor: 5.858
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.