Literature DB >> 28507110

Controlled Release of Plectasin NZ2114 from a Hybrid Silicone-Hydrogel Material for Inhibition of Staphylococcus aureus Biofilm.

Kasper Klein1, Rasmus Birkholm Grønnemose1, Martin Alm2, Karoline Sidelmann Brinch3, Hans Jørn Kolmos1, Thomas Emil Andersen4.   

Abstract

Staphylococcus aureus is a major human pathogen in catheter-related infections. Modifying catheter material with interpenetrating polymer networks is a novel material technology that allows for impregnation with drugs and subsequent controlled release. Here, we evaluated the potential for combining this system with plectasin derivate NZ2114 in an attempt to design an S. aureus biofilm-resistant catheter. The material demonstrated promising antibiofilm properties, including properties against methicillin-resistant S. aureus, thus suggesting a novel application of this antimicrobial peptide.
Copyright © 2017 American Society for Microbiology.

Entities:  

Keywords:  Staphylococcus aureus; antimicrobial peptides; biofilm formation; biofilms; catheter; catheter infections; hydrogel; plectasin

Mesh：

Substances：

Year:  2017        PMID： 28507110      PMCID： PMC5487675          DOI： 10.1128/AAC.00604-17

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

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8.  Efficacy of NZ2114, a novel plectasin-derived cationic antimicrobial peptide antibiotic, in experimental endocarditis due to methicillin-resistant Staphylococcus aureus.

Authors:  Yan Q Xiong; Wessam Abdel Hady; Antoine Deslandes; Astrid Rey; Laurent Fraisse; Hans-Henrik Kristensen; Michael R Yeaman; Arnold S Bayer
Journal:  Antimicrob Agents Chemother       Date:  2011-08-22       Impact factor: 5.191

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10.  Co-release of dicloxacillin and thioridazine from catheter material containing an interpenetrating polymer network for inhibiting device-associated Staphylococcus aureus infection.

Authors:  Michael Stenger; Kasper Klein; Rasmus B Grønnemose; Janne K Klitgaard; Hans J Kolmos; Jes S Lindholt; Martin Alm; Peter Thomsen; Thomas E Andersen
Journal:  J Control Release       Date:  2016-09-20       Impact factor: 9.776
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Journal:  Front Microbiol       Date:  2022-09-15       Impact factor: 6.064

5.  A Novel Device-Integrated Drug Delivery System for Local Inhibition of Urinary Tract Infection.

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6.  Genetic Determinants Enabling Medium-Dependent Adaptation to Nafcillin in Methicillin-Resistant Staphylococcus aureus.

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  6 in total

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