Literature DB >> 2850606

Mechanisms of bile secretion: insights from the isolated rat hepatocyte couplet.

J L Boyer1, A Gautam, J Graf.   

Abstract

This article reviews recent studies that have characterized the isolated rat hepatocyte couplet as a primary unit of canalicular bile formation. This cell culture system is proving to be particularly useful for identifying primary canalicular choleretics and for elucidating mechanisms of canalicular bile formation by electrophysiologic, fluorescent, and quantitative microscopic techniques.

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Year:  1988        PMID： 2850606     DOI： 10.1055/s-2008-1040552

Source DB:  PubMed          Journal:  Semin Liver Dis        ISSN： 0272-8087            Impact factor:   6.115


  11 in total

1.  Hepatic basolateral efflux contributes significantly to rosuvastatin disposition I: characterization of basolateral versus biliary clearance using a novel protocol in sandwich-cultured hepatocytes.

Authors:  Nathan D Pfeifer; Kyunghee Yang; Kim L R Brouwer
Journal:  J Pharmacol Exp Ther       Date:  2013-09-10       Impact factor: 4.030

2.  Bile canalicular secretion - tales from Vienna and Yale.

Authors:  James L Boyer
Journal:  Wien Med Wochenschr       Date:  2008

3.  Quantitative assessment of canalicular bile formation in isolated hepatocyte couplets using microscopic optical planimetry.

Authors:  A Gautam; O C Ng; M Strazzabosco; J L Boyer
Journal:  J Clin Invest       Date:  1989-02       Impact factor: 14.808

Review 4.  Isolated hepatocytes: use in experimental and clinical hepatology.

Authors:  A J Strain
Journal:  Gut       Date:  1994-04       Impact factor: 23.059

5.  Coordination of hormone-induced calcium signals in isolated rat hepatocyte couplets: demonstration with confocal microscopy.

Authors:  M H Nathanson; A D Burgstahler
Journal:  Mol Biol Cell       Date:  1992-01       Impact factor: 4.138

Review 6.  Cellular mechanisms of intrahepatic cholestasis.

Authors:  P J Meier-Abt
Journal:  Drugs       Date:  1990       Impact factor: 9.546

Review 7.  Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury.

Authors:  Kyunghee Yang; Cen Guo; Jeffrey L Woodhead; Robert L St Claire; Paul B Watkins; Scott Q Siler; Brett A Howell; Kim L R Brouwer
Journal:  J Pharm Sci       Date:  2016-02       Impact factor: 3.534

8.  Regulation of activity and apical targeting of the Cl-/HCO3- exchanger in rat hepatocytes.

Authors:  A Benedetti; M Strazzabosco; O C Ng; J L Boyer
Journal:  Proc Natl Acad Sci U S A       Date:  1994-01-18       Impact factor: 11.205

9.  Scanning laser cytometry: alterations induced by cholestatic agents in isolated rat hepatocyte couplets.

Authors:  N Thibault
Journal:  Cell Biol Toxicol       Date:  1994-12       Impact factor: 6.691

10.  Investigating cell-ECM contact changes in response to hypoosmotic stimulation of hepatocytes in vivo with DW-RICM.

Authors:  Tabea A Mundinger; Annika Sommerfeld; Roland Reinehr; Joachim P Spatz; Dieter Häussinger; Heike Boehm
Journal:  PLoS One       Date:  2012-10-26       Impact factor: 3.240
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