Literature DB >> 28505602

Unusual antigen presentation offers new insight into HIV vaccine design.

Andrew J McMichael1, Louis J Picker2.   

Abstract

Recent findings with a rhesus monkey cytomegalovirus based simian immunodeficiency virus vaccine have identified strong CD8+ T cell responses that are restricted by MHC-E. Also mycobacteria specific CD8+ T cells, that are MHC-E restricted, have been identified. MHC-E therefore can present a wide range of epitope peptides to CD8+ T cells, alongside its well defined role in presenting a conserved MHC-class I signal peptide to the NKG2A/C-CD94 receptor on natural killer cells. Here we explore the antigen processing pathways involved in these atypical T cell responses.
Copyright © 2017 Elsevier Ltd. All rights reserved.

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Year:  2017        PMID： 28505602      PMCID： PMC5719868          DOI： 10.1016/j.coi.2017.04.009

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  36 in total

1.  Requirement of the proteasome for the trimming of signal peptide-derived epitopes presented by the nonclassical major histocompatibility complex class I molecule HLA-E.

Authors:  Felicity A Bland; Marius K Lemberg; Andrew J McMichael; Bruno Martoglio; Veronique M Braud
Journal:  J Biol Chem       Date:  2003-06-23       Impact factor: 5.157

2.  Peptide selection by class I molecules of the major histocompatibility complex.

Authors:  T Elliott; M Smith; P Driscoll; A McMichael
Journal:  Curr Biol       Date:  1993-12-01       Impact factor: 10.834

3.  T cell killing does not require the formation of a stable mature immunological synapse.

Authors:  Marco A Purbhoo; Darrell J Irvine; Johannes B Huppa; Mark M Davis
Journal:  Nat Immunol       Date:  2004-03-28       Impact factor: 25.606

4.  HLA-E-restricted regulatory CD8(+) T cells are involved in development and control of human autoimmune type 1 diabetes.

Authors:  Hong Jiang; Steve M Canfield; Mary P Gallagher; Hong H Jiang; Yihua Jiang; Zongyu Zheng; Leonard Chess
Journal:  J Clin Invest       Date:  2010-09-27       Impact factor: 14.808

5.  Identification of a Tap-dependent leader peptide recognized by alloreactive T cells specific for a class Ib antigen.

Authors:  C J Aldrich; A DeCloux; A S Woods; R J Cotter; M J Soloski; J Forman
Journal:  Cell       Date:  1994-11-18       Impact factor: 41.582

6.  The human major histocompatibility complex class Ib molecule HLA-E binds signal sequence-derived peptides with primary anchor residues at positions 2 and 9.

Authors:  V Braud; E Y Jones; A McMichael
Journal:  Eur J Immunol       Date:  1997-05       Impact factor: 5.532

Review 7.  The emerging role of HLA-E-restricted CD8+ T lymphocytes in the adaptive immune response to pathogens and tumors.

Authors:  Gabriella Pietra; Chiara Romagnani; Claudia Manzini; Lorenzo Moretta; Maria Cristina Mingari
Journal:  J Biomed Biotechnol       Date:  2010-06-22

8.  Human Cytomegalovirus Stimulates the Synthesis of Select Akt-Dependent Antiapoptotic Proteins during Viral Entry To Promote Survival of Infected Monocytes.

Authors:  Megan A Peppenelli; Kyle C Arend; Olesea Cojohari; Nathaniel J Moorman; Gary C Chan
Journal:  J Virol       Date:  2016-01-06       Impact factor: 5.103

9.  Cytomegalovirus vectors violate CD8+ T cell epitope recognition paradigms.

Authors:  Scott G Hansen; Jonah B Sacha; Colette M Hughes; Julia C Ford; Benjamin J Burwitz; Isabel Scholz; Roxanne M Gilbride; Matthew S Lewis; Awbrey N Gilliam; Abigail B Ventura; Daniel Malouli; Guangwu Xu; Rebecca Richards; Nathan Whizin; Jason S Reed; Katherine B Hammond; Miranda Fischer; John M Turner; Alfred W Legasse; Michael K Axthelm; Paul T Edlefsen; Jay A Nelson; Jeffrey D Lifson; Klaus Früh; Louis J Picker
Journal:  Science       Date:  2013-05-24       Impact factor: 47.728

10.  Immune clearance of highly pathogenic SIV infection.

Authors:  Scott G Hansen; Michael Piatak; Abigail B Ventura; Colette M Hughes; Roxanne M Gilbride; Julia C Ford; Kelli Oswald; Rebecca Shoemaker; Yuan Li; Matthew S Lewis; Awbrey N Gilliam; Guangwu Xu; Nathan Whizin; Benjamin J Burwitz; Shannon L Planer; John M Turner; Alfred W Legasse; Michael K Axthelm; Jay A Nelson; Klaus Früh; Jonah B Sacha; Jacob D Estes; Brandon F Keele; Paul T Edlefsen; Jeffrey D Lifson; Louis J Picker
Journal:  Nature       Date:  2013-09-11       Impact factor: 49.962
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  4 in total

Review 1.  Clinical and evolutionary consequences of HIV adaptation to HLA: implications for vaccine and cure.

Authors:  Santiago Avila-Rios; Jonathan M Carlson; Mina John; Simon Mallal; Zabrina L Brumme
Journal:  Curr Opin HIV AIDS       Date:  2019-05       Impact factor: 4.283

Review 2.  Is a Human CD8 T-Cell Vaccine Possible, and if So, What Would It Take? Could a CD8+ T-Cell Vaccine Prevent Persistent HIV Infection?

Authors:  Andrew J McMichael
Journal:  Cold Spring Harb Perspect Biol       Date:  2018-09-04       Impact factor: 10.005

Review 3.  HLA-E: exploiting pathogen-host interactions for vaccine development.

Authors:  H R Sharpe; G Bowyer; S Brackenridge; T Lambe
Journal:  Clin Exp Immunol       Date:  2019-04-09       Impact factor: 4.330

Review 4.  Current Peptide and Protein Candidates Challenging HIV Therapy beyond the Vaccine Era.

Authors:  Koollawat Chupradit; Sutpirat Moonmuang; Sawitree Nangola; Kuntida Kitidee; Umpa Yasamut; Marylène Mougel; Chatchai Tayapiwatana
Journal:  Viruses       Date:  2017-09-29       Impact factor: 5.048
  4 in total

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