Literature DB >> 2850537

Thrombin stimulates Ca-channel currents in isolated frog ventricular cells.

F Markwardt1, R Albitz, T Franke, B Nilius.   

Abstract

Effects of the proteolytic enzyme thrombin in the modulation of cardiac Ca-channel currents were examined in single ventricular cells from frog myocardium, using the whole-cell voltage clamp technique (Hamill et al. 1981). Application of 3.8.10(-9) M thrombin to the bath increased the peak of the Ca-channel current by 84 +/- 35% (8 cells). Hirudin (31.10(-9) M), a specific thrombin inhibitor, blocked the thrombin-induced increase of this current. The increase in the current can be made responsible for the measured positive inotropic effects of thrombin as well as for the shift of the plateau voltage of the action potentials towards more positive values.

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Year:  1988        PMID： 2850537     DOI： 10.1007/bf00583771

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  9 in total

1.  [THE ACTION OF THROMBIN ON THE FROG HEART].

Authors:  F MARKWARDT; K O HAUSTEIN; W NUERNBERGK
Journal:  Thromb Diath Haemorrh       Date:  1964-10-15

2.  Cyclic guanosine 3',5'-monophosphate regulates the calcium current in single cells from frog ventricle.

Authors:  R Fischmeister; H C Hartzell
Journal:  J Physiol       Date:  1987-06       Impact factor: 5.182

3.  Enhancement of calcium current in Aplysia neurones by phorbol ester and protein kinase C.

Authors:  S A DeRiemer; J A Strong; K A Albert; P Greengard; L K Kaczmarek
Journal:  Nature       Date:  1985 Jan 24-30       Impact factor: 49.962

Review 4.  Responses of aortic smooth muscle to thrombin and thrombin analogues.

Authors:  D A Walz; G F Anderson; J W Fenton
Journal:  Ann N Y Acad Sci       Date:  1986       Impact factor: 5.691

5.  Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.

Authors:  O P Hamill; A Marty; E Neher; B Sakmann; F J Sigworth
Journal:  Pflugers Arch       Date:  1981-08       Impact factor: 3.657

Review 6.  Thrombin-cellular interactions.

Authors:  M A Shuman
Journal:  Ann N Y Acad Sci       Date:  1986       Impact factor: 5.691

7.  Calcium block of guinea-pig heart sodium channels with and without modification by the piperazinylindole DPI 201-106.

Authors:  B Nilius
Journal:  J Physiol       Date:  1988-05       Impact factor: 5.182

8.  Modulation of calcium channel currents in guinea-pig single ventricular heart cells by the dihydropyridine Bay K 8644.

Authors:  F Markwardt; B Nilius
Journal:  J Physiol       Date:  1988-05       Impact factor: 5.182

9.  Thrombin and C-kinase activators potentiate calcium-stimulated arachidonic acid release in human platelets.

Authors:  S P Halenda; A G Rehm
Journal:  Biochem J       Date:  1987-12-01       Impact factor: 3.857
  9 in total
  3 in total

1.  Effects of thrombin on single calcium channels in frog ventricular cells.

Authors:  F Markwardt; T Franke; R Albitz; B Nilius
Journal:  Pflugers Arch       Date:  1990-02       Impact factor: 3.657

2.  Effect of thrombin on calcium homeostasis in chick embryonic heart cells. Receptor-operated calcium entry with inositol trisphosphate and a pertussis toxin-sensitive G protein as second messengers.

Authors:  W W Chien; R Mohabir; W T Clusin
Journal:  J Clin Invest       Date:  1990-05       Impact factor: 14.808

3.  Pharmacological modification of mechanical and electrical responses of frog heart to thrombin.

Authors:  F Markwardt; T Franke; E Glusa; B Nilius
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-04       Impact factor: 3.000
  3 in total

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