Literature DB >> 28505263

Substantial Impairment of Voriconazole Clearance by High-Dose Meropenem in a Patient With Renal Failure.

Mazyar Mahmoudi1, Thorsten Brenner2, Gencay Hatiboglu3, Jürgen Burhenne1, Johanna Weiss1, Markus A Weigand2, Walter E Haefeli1.   

Abstract

A critically ill patient with multiple postoperative infections repeatedly required profound voriconazole dose reductions whenever high-dose meropenem was added. Subsequent in vitro assessment confirmed inhibition of cytochrome P450 (CYP) 2C19 and CYP3A4 by meropenem, suggesting that during meropenem treatment, narrow therapeutic index drugs metabolized by these CYPs require close monitoring.
© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  critically ill; cytochrome P450; drug interaction; meropenem; voriconazole

Mesh：

Substances：

Year:  2017        PMID： 28505263     DOI： 10.1093/cid/cix443

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  2 in total

1.  C/MIC > 4: A Potential Instrument to Predict the Efficacy of Meropenem.

Authors:  Yichang Zhao; Chenlin Xiao; Jingjing Hou; Jiamin Wu; Yiwen Xiao; Bikui Zhang; Indy Sandaradura; Hong Luo; Jinhua Li; Miao Yan
Journal:  Antibiotics (Basel)       Date:  2022-05-16

2.  Poor response to rivaroxaban in nephrotic syndrome with acute deep vein thrombosis: A case report.

Authors:  Yan Li; Yikuan Chen; Xiaotong Qi; Bangqin Hu; Qingqing Du; Yan Qian
Journal:  Medicine (Baltimore)       Date:  2019-08       Impact factor: 1.817
  2 in total

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