Literature DB >> 2850441

Nucleotide sequence analysis of 2''-aminoglycoside nucleotidyl-transferase ANT(2'') from Tn4000: its relationship with AAD(3'') and impact on Tn21 evolution.

F R Schmidt1, E J Nücken, R B Henschke.   

Abstract

Aminoglycoside 2''-O-nucleotidyltransferase (AAD(2'')) mediates bacterial resistance to dibekacin, gentamicin, kanamycin, sisomicin and tobramycin. Its coding sequence, aadB, is part of Tn21-related transposon, Tn4000. Nucleotide sequence analysis revealed the presence of an open reading frame capable of specifying a protein of 177 amino acids with a calculated molecular weight of 21,240. The predicted amino acid sequence revealed up to 27% homology to that of three nucleotidyltransferases of type AAD(3''), which are widely distributed among Gram-negatives, and to the AAD(9) from Staphylococcus aureus transposon Tn554. The regions flanking aadB suggest that its insertion into Tn21 arose from a site-specific recombination event adjacent to the aadA gene.

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Year:  1988        PMID： 2850441     DOI： 10.1111/j.1365-2958.1988.tb00081.x

Source DB:  PubMed          Journal:  Mol Microbiol        ISSN： 0950-382X            Impact factor:   3.501


  26 in total

1.  Systematic analysis of a conserved region of the aminoglycoside 6'-N-acetyltransferase type Ib.

Authors:  A Shmara; N Weinsetel; K J Dery; R Chavideh; M E Tolmasky
Journal:  Antimicrob Agents Chemother       Date:  2001-12       Impact factor: 5.191

2.  Characterization of the chromosomal aac(6')-Ic gene from Serratia marcescens.

Authors:  K J Shaw; P N Rather; F J Sabatelli; P Mann; H Munayyer; R Mierzwa; G L Petrikkos; R S Hare; G H Miller; P Bennett; P Downey
Journal:  Antimicrob Agents Chemother       Date:  1992-07       Impact factor: 5.191

3.  Cloning, sequencing, and use as a molecular probe of a gene encoding an aminoglycoside 6'-N-acetyltransferase of broad substrate profile.

Authors:  F J Terán; J E Suárez; M C Mendoza
Journal:  Antimicrob Agents Chemother       Date:  1991-04       Impact factor: 5.191

4.  Characterization of the nonenzymatic chloramphenicol resistance (cmlA) gene of the In4 integron of Tn1696: similarity of the product to transmembrane transport proteins.

Authors:  L Bissonnette; S Champetier; J P Buisson; P H Roy
Journal:  J Bacteriol       Date:  1991-07       Impact factor: 3.490

5.  Site-specific integration of genes into hot spots for recombination flanking aadA in Tn21 transposons.

Authors:  E J Nücken; R B Henschke; F R Schmidt
Journal:  Mol Gen Genet       Date:  1991-09

6.  The dhfrI trimethoprim resistance gene of Tn7 can be found at specific sites in other genetic surroundings.

Authors:  L Sundström; O Sköld
Journal:  Antimicrob Agents Chemother       Date:  1990-04       Impact factor: 5.191

7.  Expression of antibiotic resistance genes in the integrated cassettes of integrons.

Authors:  C M Collis; R M Hall
Journal:  Antimicrob Agents Chemother       Date:  1995-01       Impact factor: 5.191

8.  Detection of aac(6')-I genes in amikacin-resistant Acinetobacter spp. by PCR.

Authors:  M C Ploy; H Giamarellou; P Bourlioux; P Courvalin; T Lambert
Journal:  Antimicrob Agents Chemother       Date:  1994-12       Impact factor: 5.191

9.  Characterization of the chromosomal aac(6')-Ii gene specific for Enterococcus faecium.

Authors:  Y Costa; M Galimand; R Leclercq; J Duval; P Courvalin
Journal:  Antimicrob Agents Chemother       Date:  1993-09       Impact factor: 5.191

Review 10.  Versatility of aminoglycosides and prospects for their future.

Authors:  Sergei B Vakulenko; Shahriar Mobashery
Journal:  Clin Microbiol Rev       Date:  2003-07       Impact factor: 26.132
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