GABAB receptors and pain.

Over the past three decades the research on GABAB receptor biology and pharmacology in pain processing has been a fascinating experience. Norman Bowery's fundamental discovery of the existence of the GABAB receptor has led the way to the definition of GABAB molecular mechanisms; patterns of receptor expression in the peripheral and central nervous system; GABAB modulatory functions within the pain pathways. We are now harnessing this acquired knowledge to develop innovative approaches to the therapeutic management of chronic pain through allosteric modulation of the GABAB. Norman's legacy would be ultimately fulfilled by the development of novel analgesics that activate the GABAB receptor. This article is part of the "Special Issue Dedicated to Norman G. Bowery".