Jim Cormier1, Katherine Cone2, Janell Lanpher2, Abigail Kinens2, Terry Henderson3, Lucy Liaw3, Edward J Bilsky4, Tamara King5, Clifford J Rosen6, Glenn W Stevenson7. 1. Department of Psychology, University of New England, Biddeford, ME 04005, United States; Department of Biomedical Sciences, University of New England College of Osteopathic Medicine, Biddeford, ME 04005, United States. 2. Department of Psychology, University of New England, Biddeford, ME 04005, United States. 3. Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME 04074, United States. 4. Department of Biomedical Sciences, University of New England College of Osteopathic Medicine, Biddeford, ME 04005, United States; Center for Excellence in the Neurosciences, University of New England, United States; Department of Biomedical Sciences COM, Pacific Northwest University of Health Sciences, Yakima, WA 98901, United States. 5. Department of Biomedical Sciences, University of New England College of Osteopathic Medicine, Biddeford, ME 04005, United States; Center for Excellence in the Neurosciences, University of New England, United States. 6. Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME 04074, United States; Center for Clinical and Translational Research, Maine Medical Center Research Institute, Scarborough, ME 04074, United States. 7. Department of Psychology, University of New England, Biddeford, ME 04005, United States; Center for Excellence in the Neurosciences, University of New England, United States. Electronic address: gstevenson@une.edu.
Abstract
There is great interest in developing and utilizing non-pharmacological/non-invasive forms of therapy for osteoarthritis (OA) pain including exercise and other physical fitness regimens. AIMS: The present experiments determined the effects of prior wheel running on OA-induced weight asymmetry and trabecular bone microarchitecture. MAIN METHODS: Wheel running included 7 or 21days of prior voluntary access to wheels followed by OA induction, followed by 21days post-OA access to wheels. OA was induced with monosodium iodoacetate (MIA), and weight asymmetry was measured using a hind limb weight bearing apparatus. Bone microarchitecture was characterized using ex vivo μCT. KEY FINDINGS: Relative to saline controls, MIA (3.2mg/25μl) produced significant weight asymmetry measured on post-days (PDs) 3, 7, 14, 21 in sedentary rats. Seven days of prior running failed to alter MIA-induced weight asymmetry. In contrast, 21days of prior running resulted in complete reversal of MIA-induced weight asymmetry on all days tested. As a comparator, the opioid agonist morphine (3.2-10mg/kg) dose-dependently reversed weight asymmetry on PDs 3, 7, 14, but was ineffective in later-stage (PD 21) OA. In runners, Cohen's d (effect sizes) for OA vs. controls indicated large increases in bone volume fraction, trabecular number, trabecular thickness, and connective density in lateral compartment, and large decreases in the same parameters in medial compartment. In contrast, effect sizes were small to moderate for sedentary OA vs. SIGNIFICANCE: Results indicate that voluntary exercise may protect against OA pain, the effect varies as a function of prior exercise duration, and is associated with distinct trabecular bone modifications.
There is great interest in developing and utilizing non-pharmacological/non-invasive forms of therapy for osteoarthritis (OA) pain including exercise and other physical fitness regimens. AIMS: The present experiments determined the effects of prior wheel running on OA-induced weight asymmetry and trabecular bone microarchitecture. MAIN METHODS: Wheel running included 7 or 21days of prior voluntary access to wheels followed by OA induction, followed by 21days post-OA access to wheels. OA was induced with monosodium iodoacetate (MIA), and weight asymmetry was measured using a hind limb weight bearing apparatus. Bone microarchitecture was characterized using ex vivo μCT. KEY FINDINGS: Relative to saline controls, MIA (3.2mg/25μl) produced significant weight asymmetry measured on post-days (PDs) 3, 7, 14, 21 in sedentary rats. Seven days of prior running failed to alter MIA-induced weight asymmetry. In contrast, 21days of prior running resulted in complete reversal of MIA-induced weight asymmetry on all days tested. As a comparator, the opioid agonist morphine (3.2-10mg/kg) dose-dependently reversed weight asymmetry on PDs 3, 7, 14, but was ineffective in later-stage (PD 21) OA. In runners, Cohen's d (effect sizes) for OA vs. controls indicated large increases in bone volume fraction, trabecular number, trabecular thickness, and connective density in lateral compartment, and large decreases in the same parameters in medial compartment. In contrast, effect sizes were small to moderate for sedentary OA vs. SIGNIFICANCE: Results indicate that voluntary exercise may protect against OA pain, the effect varies as a function of prior exercise duration, and is associated with distinct trabecular bone modifications.
Authors: Jacques R Caldwell; Ronald J Rapoport; Jeffrey C Davis; Howard L Offenberg; Howard W Marker; Sanford H Roth; William Yuan; Lise Eliot; Najib Babul; Pia Mikkelsen Lynch Journal: J Pain Symptom Manage Date: 2002-04 Impact factor: 3.612
Authors: Nicola J Stagg; Heriberto P Mata; Mohab M Ibrahim; Erik J Henriksen; Frank Porreca; Todd W Vanderah; T Philip Malan Journal: Anesthesiology Date: 2011-04 Impact factor: 7.892