Literature DB >> 28504090

Wound healing in cutaneous leishmaniasis: A double edged sword of IL-10 and TGF-β.

Amir Abdoli1, Nahid Maspi2, Fatemeh Ghaffarifar3.   

Abstract

Immune responses have a crucial role during the wound healing process in cutaneous leishmaniasis (CL). However, there are several paradoxes in immunity against CL. On the one hand, regulatory cytokines interleukin (IL)-10 and transforming growth factor beta (TGF-β) increase susceptibility to CL through suppression of several proinflammatory cytokines that require for defense against CL. On the other hand, these cytokines play a pivotal role in the acceleration of wound healing process. This review discusses about the dual role of IL-10 and TGF-β during the wound healing process and immunity against CL to offer a new insight about wound healing in CL.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Cutaneous leishmaniasis; IL-10; Leishmania; TGF-β; Wound healing

Mesh：

Substances：

Year:  2017        PMID： 28504090     DOI： 10.1016/j.cimid.2017.02.001

Source DB:  PubMed          Journal:  Comp Immunol Microbiol Infect Dis        ISSN： 0147-9571            Impact factor:   2.268


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