Literature DB >> 2850405

Human colonic (Na+ + K+)-ATPase and specific ouabain binding are not influenced by lipoxygenase products or superoxide radicals.

H Allgayer1, W Kruis, E Erdmann.   

Abstract

The effects of lipoxygenase products (5-, 12-, 15-HETE, LTB4) and superoxide radicals on human colonic (Na+ + K+)-ATPase and specific ouabain binding were measured. No significant inhibition in concentrations up to 3 x 10(-5) M was observed. The results are discussed with regard to a possible role of lipoxygenase products and radicals in the pathogenesis of water and electrolyte disturbances in various diarrheal states including inflammatory bowel disease.

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Year:  1988        PMID： 2850405     DOI： 10.1007/bf01720836

Source DB:  PubMed          Journal:  Klin Wochenschr        ISSN： 0023-2173


  11 in total

1.  On the mechanism of Na+- and K+-stimulated hydrolysis of adenosine triphosphate. 1. Purification and properties of a Na+-and K+-activated ATPase from ox brain.

Authors:  W Schoner; C von Ilberg; R Kramer; W Seubert
Journal:  Eur J Biochem       Date:  1967-05

2.  Distribution of (Na+-K+)-stimulated ATPase activity in rat intestinal mucosa.

Authors:  J P Quigley; G S Gotterer
Journal:  Biochim Biophys Acta       Date:  1969-04

3.  Inhibition of human colonic (Na+ + K+)-ATPase by arachidonic and linoleic acid.

Authors:  H Allgayer; L Brown; W Kruis; E Erdmann; G Paumgartner
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-04       Impact factor: 3.000

4.  Effect of prostanoids on human intestinal Na-K-ATPase activity.

Authors:  P Sharon; F Karmeli; D Rachmilewitz
Journal:  Isr J Med Sci       Date:  1984-08

Review 5.  Oxygen radicals and human disease.

Authors:  C E Cross; B Halliwell; E T Borish; W A Pryor; B N Ames; R L Saul; J M McCord; D Harman
Journal:  Ann Intern Med       Date:  1987-10       Impact factor: 25.391

6.  Actions of sulfasalazine and 5-aminosalicylic acid as reactive oxygen scavengers in the suppression of bile acid-induced increases in colonic epithelial cell loss and proliferative activity.

Authors:  P A Craven; J Pfanstiel; R Saito; F R DeRubertis
Journal:  Gastroenterology       Date:  1987-06       Impact factor: 22.682

7.  Stimulation of colonic secretion by lipoxygenase metabolites of arachidonic acid.

Authors:  M W Musch; R J Miller; M Field; M I Siegel
Journal:  Science       Date:  1982-09-24       Impact factor: 47.728

8.  Inverse relationship between colonic (Na+ + K+)-ATPase activity and degree of mucosal inflammation in inflammatory bowel disease.

Authors:  H Allgayer; W Kruis; G Paumgartner; B Wiebecke; L Brown; E Erdmann
Journal:  Dig Dis Sci       Date:  1988-04       Impact factor: 3.199

9.  A comparison of effects of sulfasalazine and its metabolites on the metabolism of endogenous vs. exogenous arachidonic acid.

Authors:  H Allgayer; W F Stenson
Journal:  Immunopharmacology       Date:  1988 Jan-Feb

10.  Enhanced synthesis of leukotriene B4 by colonic mucosa in inflammatory bowel disease.

Authors:  P Sharon; W F Stenson
Journal:  Gastroenterology       Date:  1984-03       Impact factor: 22.682
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