David Simmons1, Shejil Kumar2, Nic Crook3, Elaine Rush4. 1. School of Medicine, Western Sydney University, Sydney, New South Wales, Australia. 2. St George Public Hospital, Sydney, New South Wales, Australia. 3. Lakes District Health Board, Rotorua, New Zealand. 4. Auckland University of Technology, Auckland, New Zealand.
Abstract
BACKGROUND: Gestational diabetes mellitus (GDM) is a risk factor for subsequent development of type 2 diabetes mellitus (T2DM). We have investigated the extent of this risk among Māori women without known diabetes. MATERIALS AND METHODS: We recruited 2786 Māori women aged 28-86 years between 2004 and 2006, without diagnosed diabetes from the Waikato and Southern Lakes regions, via media, community and general practitioner channels, and invited them for an oral glucose tolerance test (OGTT). RESULTS: Fifty (1.8%) women reported previous GDM (pGDM). The prevalence decreased significantly with age (P = 0.009). Women aged <50 years with pGDM had higher body mass index (35.6 ± 6.7 vs 32.4 ± 7.7 kg/m2 , P < 0.01), waist circumference (105.3 ± 18.8 vs 96.9 ± 16.6 cm, P < 0.01), fasting blood glucose (5.5 ± 1.0 vs 5.1 ± 0.8 mmol/L, P ≤ 0.01), two-hour post-prandial blood glucose (6.6 ± 3.0 vs 5.6 ± 2.1 mmol/L, P < 0.01) and HbA1c (6.0 ± 0.8 vs 5.8 ± 0.6%, P < 0.05) than women without pGDM. PGDM was a significant risk factor for undiagnosed diabetes (odds ratio 4.0; (5% confidence interval 1.67-9.71). Undiagnosed diabetes was significantly more prevalent among women with than without pGDM aged <40 years (20.0% vs 1.5%). CONCLUSION: Self-reported past GDM was a significant risk factor for undiagnosed diabetes in this Māori population, particularly among women aged <40 years, highlighting the importance of targeting this group for more intensive screening.
BACKGROUND:Gestational diabetes mellitus (GDM) is a risk factor for subsequent development of type 2 diabetes mellitus (T2DM). We have investigated the extent of this risk among Māori women without known diabetes. MATERIALS AND METHODS: We recruited 2786 Māori women aged 28-86 years between 2004 and 2006, without diagnosed diabetes from the Waikato and Southern Lakes regions, via media, community and general practitioner channels, and invited them for an oral glucose tolerance test (OGTT). RESULTS: Fifty (1.8%) women reported previous GDM (pGDM). The prevalence decreased significantly with age (P = 0.009). Women aged <50 years with pGDM had higher body mass index (35.6 ± 6.7 vs 32.4 ± 7.7 kg/m2 , P < 0.01), waist circumference (105.3 ± 18.8 vs 96.9 ± 16.6 cm, P < 0.01), fasting blood glucose (5.5 ± 1.0 vs 5.1 ± 0.8 mmol/L, P ≤ 0.01), two-hour post-prandial blood glucose (6.6 ± 3.0 vs 5.6 ± 2.1 mmol/L, P < 0.01) and HbA1c (6.0 ± 0.8 vs 5.8 ± 0.6%, P < 0.05) than women without pGDM. PGDM was a significant risk factor for undiagnosed diabetes (odds ratio 4.0; (5% confidence interval 1.67-9.71). Undiagnosed diabetes was significantly more prevalent among women with than without pGDM aged <40 years (20.0% vs 1.5%). CONCLUSION: Self-reported past GDM was a significant risk factor for undiagnosed diabetes in this Māori population, particularly among women aged <40 years, highlighting the importance of targeting this group for more intensive screening.