Literature DB >> 28503404

Wnt Signaling in Normal and Malignant Stem Cells.

Dheeraj Bhavanasi1, Peter S Klein1,2.   

Abstract

Wnt signaling plays important roles in stem cell self-renewal and differentiation in adults as well as in embryonic development. Mutations that activate canonical Wnt/β-catenin signaling also initiate and maintain several cancer states, including colorectal cancer and leukemia, and hence Wnt inhibitors are currently being explored as therapeutic options. In this review, we summarize previous studies and update recent findings on canonical Wnt signaling and its components, as well as their roles in somatic stem cell homeostasis and maintenance of cancer initiating cells.

Entities:  

Keywords:  Canonical Wnt signaling; GSK-3; adenomatous polyposis coli (APC); colorectal cancer; hematopoietic stem cells; mechanistic target of rapamycin (mTOR)

Year:  2016        PMID： 28503404      PMCID： PMC5423672          DOI： 10.1007/s40778-016-0068-y

Source DB:  PubMed          Journal:  Curr Stem Cell Rep


  121 in total

Review 1.  WNT signalling and haematopoiesis: a WNT-WNT situation.

Authors:  Frank J T Staal; Hans C Clevers
Journal:  Nat Rev Immunol       Date:  2005-01       Impact factor: 53.106

2.  Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway.

Authors:  Eek-hoon Jho; Tong Zhang; Claire Domon; Choun-Ki Joo; Jean-Noel Freund; Frank Costantini
Journal:  Mol Cell Biol       Date:  2002-02       Impact factor: 4.272

3.  Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C.

Authors:  D Cook; M J Fry; K Hughes; R Sumathipala; J R Woodgett; T C Dale
Journal:  EMBO J       Date:  1996-09-02       Impact factor: 11.598

4.  The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless.

Authors:  F Rijsewijk; M Schuermann; E Wagenaar; P Parren; D Weigel; R Nusse
Journal:  Cell       Date:  1987-08-14       Impact factor: 41.582

5.  Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling.

Authors:  Menno F Kielman; Maaret Rindapää; Claudia Gaspar; Nicole van Poppel; Cor Breukel; Sandra van Leeuwen; Makoto Mark Taketo; Scott Roberts; Ron Smits; Riccardo Fodde
Journal:  Nat Genet       Date:  2002-11-11       Impact factor: 38.330

6.  Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block.

Authors:  Peggy Kirstetter; Kristina Anderson; Bo T Porse; Sten Eirik W Jacobsen; Claus Nerlov
Journal:  Nat Immunol       Date:  2006-09-03       Impact factor: 25.606

7.  Identification of c-MYC as a target of the APC pathway.

Authors:  T C He; A B Sparks; C Rago; H Hermeking; L Zawel; L T da Costa; P J Morin; B Vogelstein; K W Kinzler
Journal:  Science       Date:  1998-09-04       Impact factor: 47.728

8.  Pivotal role for glycogen synthase kinase-3 in hematopoietic stem cell homeostasis in mice.

Authors:  Jian Huang; Yi Zhang; Alexey Bersenev; W Timothy O'Brien; Wei Tong; Stephen G Emerson; Peter S Klein
Journal:  J Clin Invest       Date:  2009-12       Impact factor: 14.808

9.  Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice.

Authors:  Teruaki Fujishita; Koji Aoki; Heidi A Lane; Masahiro Aoki; Makoto M Taketo
Journal:  Proc Natl Acad Sci U S A       Date:  2008-09-03       Impact factor: 11.205

10.  Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation.

Authors:  Corey Cutler; Pratik Multani; David Robbins; Haesook T Kim; Thuy Le; Jonathan Hoggatt; Louis M Pelus; Caroline Desponts; Yi-Bin Chen; Betsy Rezner; Philippe Armand; John Koreth; Brett Glotzbecker; Vincent T Ho; Edwin Alyea; Marlisa Isom; Grace Kao; Myriam Armant; Leslie Silberstein; Peirong Hu; Robert J Soiffer; David T Scadden; Jerome Ritz; Wolfram Goessling; Trista E North; John Mendlein; Karen Ballen; Leonard I Zon; Joseph H Antin; Daniel D Shoemaker
Journal:  Blood       Date:  2013-08-30       Impact factor: 22.113
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  14 in total

1.  Knockdown of eukaryotic translation initiation factor 3 subunit B inhibits cell proliferation and migration and promotes apoptosis by downregulating WNT signaling pathway in acute myeloid leukemia.

Authors:  Yonghuai Feng; Liusong Wu
Journal:  Int J Clin Exp Pathol       Date:  2020-01-01

Review 2.  Cancer stem cells: a major culprit of intra-tumor heterogeneity.

Authors:  Faiza Naz; Mengran Shi; Salvia Sajid; Zhao Yang; Changyuan Yu
Journal:  Am J Cancer Res       Date:  2021-12-15       Impact factor: 6.166

3.  Pin1 inhibition exerts potent activity against acute myeloid leukemia through blocking multiple cancer-driving pathways.

Authors:  Xiaolan Lian; Yu-Min Lin; Shingo Kozono; Megan K Herbert; Xin Li; Xiaohong Yuan; Jiangrui Guo; Yafei Guo; Min Tang; Jia Lin; Yiping Huang; Bixin Wang; Chenxi Qiu; Cheng-Yu Tsai; Jane Xie; Ziang Jeff Gao; Yong Wu; Hekun Liu; Xiao Zhen Zhou; Kun Ping Lu; Yuanzhong Chen
Journal:  J Hematol Oncol       Date:  2018-05-30       Impact factor: 17.388

4.  The role of the Wnt/β-catenin signaling pathway in the proliferation of gold nanoparticle-treated human periodontal ligament stem cells.

Authors:  Chen Li; Zhuoquan Li; Yan Zhang; Abdel Hamid Fathy; Min Zhou
Journal:  Stem Cell Res Ther       Date:  2018-08-09       Impact factor: 6.832

5.  Connexin43 Suppresses Lung Cancer Stem Cells.

Authors:  Randall J Ruch
Journal:  Cancers (Basel)       Date:  2019-02-02       Impact factor: 6.639

Review 6.  CSCs in Breast Cancer-One Size Does Not Fit All: Therapeutic Advances in Targeting Heterogeneous Epithelial and Mesenchymal CSCs.

Authors:  Andrew Sulaiman; Sarah McGarry; Xianghui Han; Sheng Liu; Lisheng Wang
Journal:  Cancers (Basel)       Date:  2019-08-07       Impact factor: 6.639

7.  Possible Contribution of Wnt-Responsive Chondroprogenitors to the Postnatal Murine Growth Plate.

Authors:  Yu Usami; Aruni T Gunawardena; Noelle B Francois; Satoru Otsuru; Hajime Takano; Katsutoshi Hirose; Masatake Matsuoka; Akiko Suzuki; Jiahui Huang; Ling Qin; Masahiro Iwamoto; Wentian Yang; Satoru Toyosawa; Motomi Enomoto-Iwamoto
Journal:  J Bone Miner Res       Date:  2019-01-28       Impact factor: 6.741

8.  HIF-2α promotes conversion to a stem cell phenotype and induces chemoresistance in breast cancer cells by activating Wnt and Notch pathways.

Authors:  Yuanyuan Yan; Fangxiao Liu; Li Han; Lin Zhao; Jianjun Chen; Olufunmilayo I Olopade; Miao He; Minjie Wei
Journal:  J Exp Clin Cancer Res       Date:  2018-10-19

9.  Gene expression signatures associated with sensitivity to azacitidine in myelodysplastic syndromes.

Authors:  Kyuryung Kim; Silvia Park; Hayoung Choi; Hye Joung Kim; Yong-Rim Kwon; Daeun Ryu; Myungshin Kim; Tae-Min Kim; Yoo-Jin Kim
Journal:  Sci Rep       Date:  2020-11-11       Impact factor: 4.379

Review 10.  Differences and similarities between cancer and somatic stem cells: therapeutic implications.

Authors:  Fiorella Rossi; Hunter Noren; Richard Jove; Vladimir Beljanski; Karl-Henrik Grinnemo
Journal:  Stem Cell Res Ther       Date:  2020-11-18       Impact factor: 6.832
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