| Literature DB >> 28502678 |
Athanasios Mavropoulos1, Christos Liaskos1, Theodora Simopoulou1, Dimitrios P Bogdanos1, Lazaros I Sakkas2.
Abstract
We aimed to analyze IL-10+ Breg (B10) cells, found to be reduced in systemic sclerosis (SSc), in relation to SSc-specific autoAbs and IL-17+ and IFNγ+ T cells in SSc. Peripheral blood B10 cells from 26 patients with SSc positive for anti-Topo I or anti-Cen autoAbs, and 12 healthy controls (HC) were studied by flow cytometry. IL-17+ and IFNγ+ T cells were also studied. B10 cells did not correlate with anti-Topo I or anti-Cen Ab levels but were inversely correlated with IL-17+ CD3+ cells and IFNγ+ CD3+ cells. IL-17+ CD3+ cells did not correlate with autoAb levels, but IFN-γ+ CD3+ cells were inversely correlated with anti-Topo I levels. In conclusion, in SSc, B10 cells did not correlate with SSc-specific autoAbs and exhibited an inverse correlation with IL-17+ T cells and IFNγ+ T cells.Entities:
Keywords: Autoantibody; Autoimmunity; B regulatory cells; Scleroderma; T cells
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Year: 2017 PMID： 28502678 DOI： 10.1016/j.clim.2017.04.013
Source DB: PubMed Journal: Clin Immunol ISSN： 1521-6616 Impact factor: 3.969