Erman Esnafoglu1, Selma Cırrık2, Sema Nur Ayyıldız3, Abdullah Erdil4, Emine Yurdakul Ertürk4, Abdullah Daglı4, Tevfik Noyan3. 1. Faculty of Medicine, Research and Training Hospital, Department of Child and Adolescent Psychiatry, Ordu University, Ordu, Turkey. Electronic address: ermanesnafoglu@yahoo.com.tr. 2. Faculty of Medicine, Department of Medical Physiology, Ordu University, Ordu, Turkey. 3. Faculty of Medicine, Research and Training Hospital, Department of Biochemistry, Ordu University, Ordu, Turkey. 4. Department of Pediatrics, Faculty of Medicine, Research and Training Hospital, Department of Pediatry, Ordu University, Ordu, Turkey.
Abstract
OBJECTIVE: To evaluate the serum levels of zonulin, which regulates tight junctions between enterocytes and is a physiological modulator controlling intestinal permeability, in patients with autism spectrum disorders (ASDs). STUDY DESIGN: Serum zonulin levels were determined in 32 patients with ASD and 33 healthy controls using an enzyme-linked immunosorbent assay. The severity of ASD symptoms was assessed with the Childhood Autism Rating Scale. RESULTS: Serum zonulin levels were significantly higher in the patients with ASD (122.3 ± 98.46 ng/mL) compared with the healthy controls (41.89 ± 45.83 ng/mL). There was a positive correlation between zonulin levels and Childhood Autism Rating Scale score when all subjects were assessed (r = 0.523; P < .001). CONCLUSIONS: This study suggests that zonulin, which regulates intestinal permeability, plays a role in the development of symptoms of ASD.
OBJECTIVE: To evaluate the serum levels of zonulin, which regulates tight junctions between enterocytes and is a physiological modulator controlling intestinal permeability, in patients with autism spectrum disorders (ASDs). STUDY DESIGN: Serum zonulin levels were determined in 32 patients with ASD and 33 healthy controls using an enzyme-linked immunosorbent assay. The severity of ASD symptoms was assessed with the Childhood Autism Rating Scale. RESULTS: Serum zonulin levels were significantly higher in the patients with ASD (122.3 ± 98.46 ng/mL) compared with the healthy controls (41.89 ± 45.83 ng/mL). There was a positive correlation between zonulin levels and Childhood Autism Rating Scale score when all subjects were assessed (r = 0.523; P < .001). CONCLUSIONS: This study suggests that zonulin, which regulates intestinal permeability, plays a role in the development of symptoms of ASD.
Authors: Kavi M Rude; Matteo M Pusceddu; Ciara E Keogh; Jessica A Sladek; Gonzalo Rabasa; Elaine N Miller; Sunjay Sethi; Kimberly P Keil; Isaac N Pessah; Pamela J Lein; Mélanie G Gareau Journal: Environ Pollut Date: 2019-07-14 Impact factor: 8.071
Authors: N E Kushlinskii; E S Gershtein; N N Zybina; P V Tsarapaev; E P Salyanova; E A Korotkova; E L Nikonov; Z Z Mamedli; V K Bozhenko; I S Stilidi Journal: Bull Exp Biol Med Date: 2022-07-19 Impact factor: 0.737
Authors: Mohammed U Alamoudi; Suzanne Hosie; Anya E Shindler; Jennifer L Wood; Ashley E Franks; Elisa L Hill-Yardin Journal: Front Cell Infect Microbiol Date: 2022-07-01 Impact factor: 6.073
Authors: Alba Miranda-Ribera; Gloria Serena; Jundi Liu; Alessio Fasano; Marcy A Kingsbury; Maria R Fiorentino Journal: Tissue Barriers Date: 2021-11-14