Literature DB >> 28501981

Protective Effect of Gentianine, a compound from Du Huo Ji Sheng Tang, against Freund's Complete Adjuvant-Induced Arthritis in Rats.

Chen Wenjin1, Wang Jianwei2.   

Abstract

The anti-inflammatory property of gentianine (GE) aroused our interest. To investigate the effect of GE on Freund's complete adjuvant (FCA)-induced arthritis in rats was the aim of this study. Adjuvant-induced arthritis (AA) was induced by the administration of 0.1 ml FCA in the surface of hind paw. Diclofenac sodium (DS) and Fasudil were administered as positive controls. Downregulation of cytokines including interleukin-6 (IL-6), interleukin-1 beta (IL-1β), and tumor necrosis factor-alpha (TNF-α) revealed anti-inflammatory effect of GE, which was consisted with pathological conditions of rat paws. In addition, western blot analysis revealed that GE could strikingly suppressed the expressions of Rho/NF-κB signaling pathways as well as TGF-β/smad-3 pathways. In conclusion, data indicated that GE might contribute to treat arthritis as a potential therapeutic candidate.

Entities:  

Keywords:  Freund’s complete adjuvant; arthritis; gentianine; inflammation

Mesh：

Substances：

Year:  2017        PMID： 28501981     DOI： 10.1007/s10753-017-0583-8

Source DB:  PubMed          Journal:  Inflammation        ISSN： 0360-3997            Impact factor:   4.092


  24 in total

Review 1.  Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells.

Authors:  K Kaibuchi; S Kuroda; M Amano
Journal:  Annu Rev Biochem       Date:  1999       Impact factor: 23.643

Review 2.  Many cytokines are very useful therapeutic targets in disease.

Authors:  Marc Feldmann
Journal:  J Clin Invest       Date:  2008-11       Impact factor: 14.808

3.  Protective effect of apigenin on Freund's complete adjuvant-induced arthritis in rats via inhibiting P2X7/NF-κB pathway.

Authors:  Xiayun Chang; He He; Lingpeng Zhu; Jin Gao; Tingting Wei; Zhanqian Ma; Tianhua Yan
Journal:  Chem Biol Interact       Date:  2015-04-29       Impact factor: 5.192

4.  Effects of Naringenin on inflammation in complete freund's adjuvant-induced arthritis by regulating Bax/Bcl-2 balance.

Authors:  Lingpeng Zhu; Jing Wang; Tingting Wei; Jin Gao; He He; Xiayun Chang; Tianhua Yan
Journal:  Inflammation       Date:  2015-02       Impact factor: 4.092

5.  The protective effect of CDDO-Me on lipopolysaccharide-induced acute lung injury in mice.

Authors:  Tong Chen; Yi Mou; Jiani Tan; Linlin Wei; Yixue Qiao; Tingting Wei; Pengjun Xiang; Sixun Peng; Yihua Zhang; Zhangjian Huang; Hui Ji
Journal:  Int Immunopharmacol       Date:  2015-01-19       Impact factor: 4.932

6.  Liujunzi Tang, a famous traditional Chinese medicine, ameliorates cigarette smoke-induced mouse model of COPD.

Authors:  Rui Zhou; Fen Luo; Hui Lei; Kai Zhang; Jingyan Liu; He He; Jin Gao; Xiayun Chang; Ling He; Hui Ji; Tianhua Yan; Tong Chen
Journal:  J Ethnopharmacol       Date:  2016-09-19       Impact factor: 4.360

7.  Membrane-associated IL-1 contributes to chronic synovitis and cartilage destruction in human IL-1 alpha transgenic mice.

Authors:  Yasuo Niki; Harumoto Yamada; Toshiyuki Kikuchi; Yoshiaki Toyama; Hideo Matsumoto; Kyosuke Fujikawa; Norihiro Tada
Journal:  J Immunol       Date:  2004-01-01       Impact factor: 5.422

8.  Protective Effect of Astragaloside IV Against Paraquat-Induced Lung Injury in Mice by Suppressing Rho Signaling.

Authors:  Tong Chen; Ruoning Wang; Wenjiao Jiang; Huimin Wang; Ang Xu; Guo Lu; Yi Ren; Yangmei Xu; Yangyang Song; Shoulei Yong; Hui Ji; Zhanqiang Ma
Journal:  Inflammation       Date:  2016-02       Impact factor: 4.092

Review 9.  Interleukin-6 subfamily cytokines and rheumatoid arthritis: role of antagonists.

Authors:  Jalal A Jazayeri; Graeme J Carroll; Ann B Vernallis
Journal:  Int Immunopharmacol       Date:  2009-10-03       Impact factor: 4.932

10.  Role of Sinomenine on Complete Freund's Adjuvant-Induced Arthritis in Rats.

Authors:  Zhou Lan; Meng Wei; Lvyi Chen; Guangjing Xie; Xiao Liu; Xiuqiao Zhang
Journal:  IUBMB Life       Date:  2016-04-15       Impact factor: 3.885
View more
  2 in total

1.  Duhuo Jisheng Decoction inhibits SDF-1-induced inflammation and matrix degradation in human degenerative nucleus pulposus cells in vitro through the CXCR4/NF-κB pathway.

Authors:  Zong-Chao Liu; Zhen-Long Wang; Chen-Yi Huang; Zhi-Jiang Fu; Yong Liu; Zhang-Chao Wei; Shi-Gui Liu; Chuan Ma; Jie-Liang Shen; Dayue Darrel Duan
Journal:  Acta Pharmacol Sin       Date:  2018-05-24       Impact factor: 6.150

2.  Association of Chinese Herbal Medicines Use with Development of Chronic Obstructive Pulmonary Disease Among Patients with Rheumatoid Arthritis: A Population-Based Cohort Study.

Authors:  Miao-Chiu Lin; Hanoch Livneh; Wei-Jen Chen; Ming-Chi Lu; Ning-Sheng Lai; Tzung-Yi Tsai
Journal:  Int J Chron Obstruct Pulmon Dis       Date:  2020-03-30
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.