Ihsan Yilmaz1, Osman Bulut Ocak2, Basak Saracoglu Yilmaz2, Aslı Inal2, Birsen Gokyigit2, Muhittin Taskapili2. 1. Department of Ophthalmology, University of Health Sciences, Beyoglu Eye Training and Research Hospital, Istanbul. Electronic address: ihsanyilmaz.dr@gmail.com. 2. Department of Ophthalmology, University of Health Sciences, Beyoglu Eye Training and Research Hospital, Istanbul.
Abstract
PURPOSE: To quantify vessel density of superficial capillary plexus (SCP), deep capillary plexus (DCP), and the foveal avascular zone (FAZ) of children's amblyopic eyes and to compare the measurements with those of companion eyes and age-matched controls. METHODS: Fifteen patients with strabismic amblyopia, and 15 age-matched controls were included in this cross-sectional study. SCP, DCP, and FAZ were measured via optical coherence tomographic angiography (OCTA). RESULTS: Mean subject age was 8.2 ± 2.3 years in the amblyopia group and 8.6 ± 2.2 years in the control group. The mean SCP at 1 mm, 2 mm, and 3 mm zones were (in the order amblyopic eye, companion eye, control) 1.399 ± 0.088, 5.854 ± 0.195, 12.866 ± 0.346; 1.467 ± 0.084, 5.979 ± 0.182, 12.965 ± 0.321; and 1.559 ± 0.052, 6.343 ± 0.190, 13.819 ± 0.423. SCP was significantly lower in amblyopic eyes than in companion eyes and controls (P < 0.05). The mean DCP at 1 mm, 2 mm, and 3 mm zones were 1.425 ± 0.069, 6.038 ± 0.186, 13.522 ± 0.336; 1.525 ± 0.072, 6.427 ± 0.190, 14.286 ± 0.322; and 1.685 ± 0.074, 6.895 ± 0.198, 15.355 ± 0.356. DCP was significantly lower in amblyopic eyes than companion eyes and controls (P < 0.05). The mean superficial FAZ were 0.287 ± 0.091, 0.262 ± 0.092, and 0.280 ± 0.097. The mean deep FAZ were 0.382 ± 0.092, 0.335 ± 0.080, and 0.329 ± 0.085. There was no significant difference in FAZ among groups (P > 0.05). CONCLUSIONS: Vessel density of SCP and DCP of eyes with amblyopia is lower than that of the companion eye and the age-matched controls.
PURPOSE: To quantify vessel density of superficial capillary plexus (SCP), deep capillary plexus (DCP), and the foveal avascular zone (FAZ) of children's amblyopic eyes and to compare the measurements with those of companion eyes and age-matched controls. METHODS: Fifteen patients with strabismic amblyopia, and 15 age-matched controls were included in this cross-sectional study. SCP, DCP, and FAZ were measured via optical coherence tomographic angiography (OCTA). RESULTS: Mean subject age was 8.2 ± 2.3 years in the amblyopia group and 8.6 ± 2.2 years in the control group. The mean SCP at 1 mm, 2 mm, and 3 mm zones were (in the order amblyopic eye, companion eye, control) 1.399 ± 0.088, 5.854 ± 0.195, 12.866 ± 0.346; 1.467 ± 0.084, 5.979 ± 0.182, 12.965 ± 0.321; and 1.559 ± 0.052, 6.343 ± 0.190, 13.819 ± 0.423. SCP was significantly lower in amblyopic eyes than in companion eyes and controls (P < 0.05). The mean DCP at 1 mm, 2 mm, and 3 mm zones were 1.425 ± 0.069, 6.038 ± 0.186, 13.522 ± 0.336; 1.525 ± 0.072, 6.427 ± 0.190, 14.286 ± 0.322; and 1.685 ± 0.074, 6.895 ± 0.198, 15.355 ± 0.356. DCP was significantly lower in amblyopic eyes than companion eyes and controls (P < 0.05). The mean superficial FAZ were 0.287 ± 0.091, 0.262 ± 0.092, and 0.280 ± 0.097. The mean deep FAZ were 0.382 ± 0.092, 0.335 ± 0.080, and 0.329 ± 0.085. There was no significant difference in FAZ among groups (P > 0.05). CONCLUSIONS: Vessel density of SCP and DCP of eyes with amblyopia is lower than that of the companion eye and the age-matched controls.
Authors: Emily S Wong; Xiu-Juan Zhang; Nan Yuan; Jian Li; C P Pang; Lijia Chen; Clement C Tham; Carol Y Cheung; Jason C Yam Journal: JAMA Ophthalmol Date: 2020-08-01 Impact factor: 7.389