Literature DB >> 2850087

Voltage-clamp analysis of a transient potassium current in rat neostriatal neurons.

D J Surmeier1, J Bargas, S T Kitai.   

Abstract

Whole cell voltage-clamp recordings were made from cultured rat neostriatal neurons. Depolarizing voltage commands evoked transient and sustained outward K-currents. The transient K-current was activated by depolarizing commands beyond -50 mV; peak current was dependent upon holding potential. Bath application of 4-aminopyridine, but not inorganic calcium channel blockers (Cd, Co, Mn), attenuated the transient current. Reversal was near the K-equilibrium potential. These properties suggest that this transient K-current is similar to the A-current described in a number of other neurons.

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Year:  1988        PMID： 2850087     DOI： 10.1016/0006-8993(88)90334-4

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  8 in total

1.  Unitary A-currents of rat locus coeruleus neurones grown in cell culture: rectification caused by internal Mg2+ and Na+.

Authors:  I D Forsythe; P Linsdell; P R Stanfield
Journal:  J Physiol       Date:  1992       Impact factor: 5.182

2.  Up and down states in striatal medium spiny neurons simultaneously recorded with spontaneous activity in fast-spiking interneurons studied in cortex-striatum-substantia nigra organotypic cultures.

Authors:  D Plenz; S T Kitai
Journal:  J Neurosci       Date:  1998-01-01       Impact factor: 6.167

3.  An early outward conductance modulates the firing latency and frequency of neostriatal neurons of the rat brain.

Authors:  J Bargas; E Galarraga; J Aceves
Journal:  Exp Brain Res       Date:  1989       Impact factor: 1.972

4.  Interactions of glutamate and dopamine in a computational model of the striatum.

Authors:  R Kötter; J Wickens
Journal:  J Comput Neurosci       Date:  1995-09       Impact factor: 1.621

5.  The potassium A-current, low firing rates and rebound excitation in Hodgkin-Huxley models.

Authors:  M E Rush; J Rinzel
Journal:  Bull Math Biol       Date:  1995-11       Impact factor: 1.758

6.  Somatodendritic depolarization-activated potassium currents in rat neostriatal cholinergic interneurons are predominantly of the A type and attributable to coexpression of Kv4.2 and Kv4.1 subunits.

Authors:  W J Song; T Tkatch; G Baranauskas; N Ichinohe; S T Kitai; D J Surmeier
Journal:  J Neurosci       Date:  1998-05-01       Impact factor: 6.167

7.  Halothane anesthesia affects NMDA-stimulated cholinergic and GABAergic modulation of striatal dopamine efflux and metabolism in the rat in vivo.

Authors:  K J Whitehead; S Rose; P Jenner
Journal:  Neurochem Res       Date:  2004-04       Impact factor: 3.996

8.  Subthreshold rectification in neostriatal spiny projection neurons.

Authors:  E Galarraga; M T Pacheco-Cano; J V Flores-Hernández; J Bargas
Journal:  Exp Brain Res       Date:  1994       Impact factor: 1.972
  8 in total

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