INTRODUCTION: The aim of this study was to follow circulating brain-derived neurotrophic factor (BDNF) and interleukin-6 (IL-6) levels in response to severe muscle-damaging exercise. METHODS: Young healthy men (N = 10) performed a bout of mechanically demanding stretch-shortening cycle exercise consisting of 200 drop jumps. Voluntary and electrically induced knee extension torque, serum BDNF levels, and IL-6 levels were measured before and for up to 7 days after exercise. RESULTS: Muscle force decreased by up to 40% and did not recover by 24 hours after exercise. Serum BDNF was decreased 1 hour and 24 hours after exercise, whereas IL-6 increased immediately and 1 hour after but recovered to baseline by 24 hours after exercise. IL-6 and 100-Hz stimulation torque were correlated (r = -0.64, P < 0.05) 24 hours after exercise. DISCUSSION: In response to acute, severe muscle-damaging exercise, serum BDNF levels decrease, whereas IL-6 levels increase and are associated with peripheral fatigue. Muscle Nerve 57: E46-E51, 2018.
INTRODUCTION: The aim of this study was to follow circulating brain-derived neurotrophic factor (BDNF) and interleukin-6 (IL-6) levels in response to severe muscle-damaging exercise. METHODS: Young healthy men (N = 10) performed a bout of mechanically demanding stretch-shortening cycle exercise consisting of 200 drop jumps. Voluntary and electrically induced knee extension torque, serum BDNF levels, and IL-6 levels were measured before and for up to 7 days after exercise. RESULTS: Muscle force decreased by up to 40% and did not recover by 24 hours after exercise. Serum BDNF was decreased 1 hour and 24 hours after exercise, whereas IL-6 increased immediately and 1 hour after but recovered to baseline by 24 hours after exercise. IL-6 and 100-Hz stimulation torque were correlated (r = -0.64, P < 0.05) 24 hours after exercise. DISCUSSION: In response to acute, severe muscle-damaging exercise, serum BDNF levels decrease, whereas IL-6 levels increase and are associated with peripheral fatigue. Muscle Nerve 57: E46-E51, 2018.
Authors: T Venckunas; R Krusnauskas; A Snieckus; N Eimantas; N Baranauskiene; A Skurvydas; M Brazaitis; S Kamandulis Journal: Eur J Appl Physiol Date: 2019-06-04 Impact factor: 3.078
Authors: María A Domínguez-Sanchéz; Rosa H Bustos-Cruz; Gina P Velasco-Orjuela; Andrea P Quintero; Alejandra Tordecilla-Sanders; Jorge E Correa-Bautista; Héctor R Triana-Reina; Antonio García-Hermoso; Katherine González-Ruíz; Carlos A Peña-Guzmán; Enrique Hernández; Jhonatan C Peña-Ibagon; Luis A Téllez-T; Mikel Izquierdo; Robinson Ramírez-Vélez Journal: Front Physiol Date: 2018-06-27 Impact factor: 4.566