Po-Han Chou1, Wei-Hao Lin2, Wang-Rung Li2, Chih-Mao Huang3, Chia-Wei Sun4. 1. Department of Psychiatry, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Photonics, National Chiao Tung University, Hsinchu, Taiwan; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan; Department of Psychiatry, School of Medicine, National Yang-Ming University, Taiwan. Electronic address: phchou1980@gmail.com. 2. Department of Psychiatry, Taichung Veterans General Hospital, Taichung, Taiwan. 3. Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan. 4. Department of Photonics, National Chiao Tung University, Hsinchu, Taiwan.
Abstract
BACKGROUND: Diminished functional lateralization in language-related areas is found in chronic schizophrenia (SZ). However, whether this reduced lateralization exists at the early stage of SZ remains unclear. The present study aimed to investigate language lateralization in first episode schizophrenia (FES) using near infrared spectroscopy (NIRS) during a letter version of verbal fluency test (VFT). METHODS: A total of 28 FES patients and 33 healthy controls (HCs) underwent NIRS while performing a VFT. Six regions of interests (ROIs) were defined: the bilateral frontal-, inferior frontal gyrus (IFG), and temporal regions. Laterality index (LI) was calculated and compared between the two groups in ROIs. In addition, we investigated whether language lateralization was correlated with severity of clinical symptoms. RESULTS: Across all ROIs, LI was significantly reduced in FES patients (p=0.037) compared to controls in the IFG region. In addition, LI was not found to be correlated with VFT performance, the PANSS positive, negative or general psychopathology subscales. CONCLUSIONS: Our study demonstrated a diminution of leftward functional lateralization in the IFG during a VFT in FES patients. This is the first NIRS study to report reduced functional lateralization in patients at the early stage of schizophrenia.
BACKGROUND: Diminished functional lateralization in language-related areas is found in chronic schizophrenia (SZ). However, whether this reduced lateralization exists at the early stage of SZ remains unclear. The present study aimed to investigate language lateralization in first episode schizophrenia (FES) using near infrared spectroscopy (NIRS) during a letter version of verbal fluency test (VFT). METHODS: A total of 28 FES patients and 33 healthy controls (HCs) underwent NIRS while performing a VFT. Six regions of interests (ROIs) were defined: the bilateral frontal-, inferior frontal gyrus (IFG), and temporal regions. Laterality index (LI) was calculated and compared between the two groups in ROIs. In addition, we investigated whether language lateralization was correlated with severity of clinical symptoms. RESULTS: Across all ROIs, LI was significantly reduced in FES patients (p=0.037) compared to controls in the IFG region. In addition, LI was not found to be correlated with VFT performance, the PANSS positive, negative or general psychopathology subscales. CONCLUSIONS: Our study demonstrated a diminution of leftward functional lateralization in the IFG during a VFT in FES patients. This is the first NIRS study to report reduced functional lateralization in patients at the early stage of schizophrenia.
Authors: Julio Sanjuán; Xochitl Helga Castro-Martínez; Gracián García-Martí; Javier González-Fernández; Roberto Sanz-Requena; Josep María Haro; J Javier Meana; Luis Martí-Bonmatí; Juan Nacher; Noelia Sebastiá-Ortega; Javier Gilabert-Juan; María Dolores Moltó Journal: Brain Imaging Behav Date: 2021-06 Impact factor: 3.978