Literature DB >> 28499733

Alkaloids from aerial parts of Houttuynia cordata and their anti-inflammatory activity.

Jongmin Ahn1, Hee-Sung Chae2, Young-Won Chin2, Jinwoong Kim3.   

Abstract

New alkaloids, houttuynamide B and C (1, 2) and houttuycorine (14), were isolated from the aerial parts of Houttuynia cordata Thunb. in addition to eighteen known alkaloids. Their structures were elucidated through extensive spectroscopic analysis. All the isolates were tested for their inhibitory activity against NO production in RAW 264.7 cells stimulated by LPS. Of the tested compounds, compound 15 showed the most potent anti-inflammatory activity with an IC50 value of 8.7μM.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Alkaloids; Anti-inflammatory; Benzamides; Houttuynia cordata; β-Carboline alkaloid

Mesh：

Substances：

Year:  2017        PMID： 28499733     DOI： 10.1016/j.bmcl.2017.04.072

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Efficacy of Houttuynia eye drops for the treatment of vernal keratoconjunctivitis: A systemic review and meta-analysis protocol.

Authors:  Lingyan Yu; Xueying Chen; Zhenwei Yu
Journal:  Medicine (Baltimore)       Date:  2019-06       Impact factor: 1.817

2.  Houttuynia cordata polysaccharide alleviated intestinal injury and modulated intestinal microbiota in H1N1 virus infected mice.

Authors:  Mei-Yu Chen; Hong Li; Xiao-Xiao Lu; Li-Jun Ling; Hong-Bo Weng; Wei Sun; Dao-Feng Chen; Yun-Yi Zhang
Journal:  Chin J Nat Med       Date:  2019-03

3.  Predicting for anti-(mutant) SARS-CoV-2 and anti-inflammation compounds of Lianhua Qingwen Capsules in treating COVID-19.

Authors:  Liang Hong; Min He; Shaoping Li; Jing Zhao
Journal:  Chin Med       Date:  2022-07-07       Impact factor: 4.546

Review 4.  The therapeutic potential of Houttuynia cordata: A current review.

Authors:  C Laldinsangi
Journal:  Heliyon       Date:  2022-08-24

Review 5.  Traditional Chinese Medicine as a Potential Source for HSV-1 Therapy by Acting on Virus or the Susceptibility of Host.

Authors:  Wen Li; Xiao-Hua Wang; Zhuo Luo; Li-Fang Liu; Chang Yan; Chang-Yu Yan; Guo-Dong Chen; Hao Gao; Wen-Jun Duan; Hiroshi Kurihara; Yi-Fang Li; Rong-Rong He
Journal:  Int J Mol Sci       Date:  2018-10-20       Impact factor: 5.923
  5 in total

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