Mei Liu1, Lu Li2, Su-Jun Zheng1, Jing Zhao1, Gabor S Ungvari3, Brian J Hall4, Zhong-Ping Duan5, Yu-Tao Xiang6. 1. Artificial Liver Center, Beijing YouAn Hospital, Capital Medical University, Beijing, China. 2. Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China. 3. The University of Notre Dame Australia/Marian Centre, Perth, Australia; School of Psychiatry & Clinical Neurosciences, University of Western Australia, Perth, Australia. 4. Global and Community Mental Health Research Group, Department of Psychology, University of Macau, Macao SAR, China; Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. 5. Artificial Liver Center, Beijing YouAn Hospital, Capital Medical University, Beijing, China. Electronic address: duan2517@163.com. 6. Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China. Electronic address: xyutly@gmail.com.
Abstract
BACKGROUND: There are no data about the frequency of major depression in patients with liver disease related to Hepatitis B virus (HBV) in China. This study examined the prevalence of major depression and its clinical correlates and association with quality of life (QOL) in patients with HBV-related liver diseases. METHOD: Altogether 634 patients with HBV-related liver diseases met study entry criteria and completed the survey. The diagnosis of major depression was established with the Mini International Neuropsychiatric Interview (MINI). Socio-demographic and clinical characteristics, Global Assessment of Functioning (GAF) and QOL were measured. RESULTS: The prevalence of major depression was 6.4%. Multivariable logistic regression analyses revealed that insomnia (P=0.01, OR=5.5, 95%CI=1.4-21.6) and global functioning (P<0.001, OR=0.6, 95% CI=0.5-0.7) were independently associated with major depression. Major depression was associated with both poor physical (F (1, 634)=4.0, P=0.04) and mental QOL (F (1, 634)=26.2, P<0.001). CONCLUSIONS: Given the negative impact of depression on patients' QOL, more attempts should be made to identify and treat it in HBV-related diseases.
BACKGROUND: There are no data about the frequency of major depression in patients with liver disease related to Hepatitis B virus (HBV) in China. This study examined the prevalence of major depression and its clinical correlates and association with quality of life (QOL) in patients with HBV-related liver diseases. METHOD: Altogether 634 patients with HBV-related liver diseases met study entry criteria and completed the survey. The diagnosis of major depression was established with the Mini International Neuropsychiatric Interview (MINI). Socio-demographic and clinical characteristics, Global Assessment of Functioning (GAF) and QOL were measured. RESULTS: The prevalence of major depression was 6.4%. Multivariable logistic regression analyses revealed that insomnia (P=0.01, OR=5.5, 95%CI=1.4-21.6) and global functioning (P<0.001, OR=0.6, 95% CI=0.5-0.7) were independently associated with major depression. Major depression was associated with both poor physical (F (1, 634)=4.0, P=0.04) and mental QOL (F (1, 634)=26.2, P<0.001). CONCLUSIONS: Given the negative impact of depression on patients' QOL, more attempts should be made to identify and treat it in HBV-related diseases.
Authors: Thuc Thi Minh Vu; Thieu Van Le; Anh Kim Dang; Long Hoang Nguyen; Binh Cong Nguyen; Bach Xuan Tran; Carl A Latkin; Cyrus S H Ho; Roger C M Ho Journal: Int J Environ Res Public Health Date: 2019-01-17 Impact factor: 3.390