Grant S Schulert1, Francesca Minoia2, John Bohnsack3, Randy Q Cron4, Soah Hashad5, Isabelle KonÉ-Paut6, Mikhail Kostik7, Daniel Lovell1, Despoina Maritsi8, Peter A Nigrovic9, Priyankar Pal10, Angelo Ravelli2, Masaki Shimizu11, Valda Stanevicha12, Sebastiaan Vastert13, Andreas Woerner14, Fabrizio de Benedetti15, Alexei A Grom1. 1. Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio. 2. Istituto Giannina Gaslini, Genoa, Italy. 3. University of Utah, Salt Lake City. 4. University of Alabama at Birmingham. 5. Tripoli Children's Hospital, Tripoli, Libya. 6. Hopital Kremlin Bicetre, CEREMAI, APHP, and University of Paris SUD, Paris, France. 7. State Pediatric Medical University, Saint Petersburg, Russia. 8. Aglaia Kyriakou Children's Hospital, University of Athens, Athens, Greece. 9. Brigham and Women's Hospital and Boston Children's Hospital, Boston, Massachusetts. 10. Institute of Child Health, Kolkata, India. 11. Kanazawa University, Kanazawa, Japan. 12. Riga Stradins University, Riga, Latvia. 13. Wilhelmina Children's Hospital, UMC Utrecht, Utrecht, The Netherlands. 14. University of Basel Children's Hospital, Basel, Switzerland. 15. IRCCS Ospedale Pediatrico Bambino Gesu, Rome, Italy.
Abstract
OBJECTIVE: To assess performance of the 2016 macrophage activation syndrome (MAS) classification criteria for patients with systemic juvenile idiopathic arthritis (JIA) who develop MAS while treated with biologic medications. METHODS: A systematic literature review was performed to identify patients with MAS while being treated with interleukin (IL)-1 and IL-6 blocking agents. Clinical and laboratory information was compared to a large previously compiled historical cohort. RESULTS: Eighteen publications were identified, and after removing duplicates, 35 patients treated with canakinumab and 49 patients with tocilizumab were available for analysis; 5 anakinra-treated patients were excluded due to limited numbers. MAS classification criteria were less likely to classify tocilizumab-treated patients as having MAS compared to the historical cohort or canakinumab-treated patients (56.7%, 78.5%, and 84%, respectively; P < 0.01). Patients who developed MAS while treated with canakinumab trended towards lower ferritin at MAS onset than the historical cohort (4,050 versus 5,353 ng/ml; P = 0.18) but had no differences in other cardinal clinical or laboratory features. In comparison, patients who developed MAS while treated with tocilizumab were less likely febrile and had notably lower ferritin levels (1,152 versus 5,353 ng/ml; P < 0.001). Other features of MAS were more pronounced in patients treated with tocilizumab, including lower platelet counts, lower fibrinogen, and higher aspartate aminotransferase levels. Mortality rates for patients with MAS treated with tocilizumab or canakinumab were not significantly different from the historical cohort. CONCLUSION: These findings show substantial alterations in MAS features that may limit utility of defined criteria for diagnosis of systemic JIA patients treated with biologic agents.
OBJECTIVE: To assess performance of the 2016 macrophage activation syndrome (MAS) classification criteria for patients with systemic juvenile idiopathic arthritis (JIA) who develop MAS while treated with biologic medications. METHODS: A systematic literature review was performed to identify patients with MAS while being treated with interleukin (IL)-1 and IL-6 blocking agents. Clinical and laboratory information was compared to a large previously compiled historical cohort. RESULTS: Eighteen publications were identified, and after removing duplicates, 35 patients treated with canakinumab and 49 patients with tocilizumab were available for analysis; 5 anakinra-treated patients were excluded due to limited numbers. MAS classification criteria were less likely to classify tocilizumab-treated patients as having MAS compared to the historical cohort or canakinumab-treated patients (56.7%, 78.5%, and 84%, respectively; P < 0.01). Patients who developed MAS while treated with canakinumab trended towards lower ferritin at MAS onset than the historical cohort (4,050 versus 5,353 ng/ml; P = 0.18) but had no differences in other cardinal clinical or laboratory features. In comparison, patients who developed MAS while treated with tocilizumab were less likely febrile and had notably lower ferritin levels (1,152 versus 5,353 ng/ml; P < 0.001). Other features of MAS were more pronounced in patients treated with tocilizumab, including lower platelet counts, lower fibrinogen, and higher aspartate aminotransferase levels. Mortality rates for patients with MAS treated with tocilizumab or canakinumab were not significantly different from the historical cohort. CONCLUSION: These findings show substantial alterations in MAS features that may limit utility of defined criteria for diagnosis of systemic JIA patients treated with biologic agents.
Authors: Shima Yasin; Ndate Fall; Rachel A Brown; Maggie Henderlight; Scott W Canna; Charlotte Girard-Guyonvarc'h; Cem Gabay; Alexei A Grom; Grant S Schulert Journal: Rheumatology (Oxford) Date: 2020-02-01 Impact factor: 7.580
Authors: Mikhail M Kostik; Eugenia A Isupova; Konstantin Belozerov; Tatyana S Likhacheva; Evgeny N Suspitsin; Rinat Raupov; Vera V Masalova; Irina A Chikova; Margarita F Dubko; Olga V Kalashnikova; Vyacheslav G Chasnyk; Randy Q Cron Journal: Front Pediatr Date: 2022-07-28 Impact factor: 3.569
Authors: Grant S Schulert; Shima Yasin; Brenna Carey; Claudia Chalk; Thuy Do; Andrew H Schapiro; Ammar Husami; Allen Watts; Hermine I Brunner; Jennifer Huggins; Elizabeth D Mellins; Esi M Morgan; Tracy Ting; Bruce C Trapnell; Kathryn A Wikenheiser-Brokamp; Christopher Towe; Alexei A Grom Journal: Arthritis Rheumatol Date: 2019-10-01 Impact factor: 10.995
Authors: Pui Y Lee; Grant S Schulert; Scott W Canna; Yuelong Huang; Jacob Sundel; Ying Li; Kacie J Hoyt; Rachel B Blaustein; Alexandra Wactor; Thuy Do; Olha Halyabar; Margaret H Chang; Fatma Dedeoglu; Siobhan M Case; Esra Meidan; Mindy S Lo; Robert P Sundel; Edward T Richardson; Jane W Newburger; Michael S Hershfield; Mary Beth Son; Lauren A Henderson; Peter A Nigrovic Journal: Ann Rheum Dis Date: 2019-11-09 Impact factor: 19.103
Authors: Laura J Janke; Denise M Imai; Heather Tillman; Rosalinda Doty; Mark J Hoenerhoff; Jiajie J Xu; Zachary T Freeman; Portia Allen; Natalie Wall Fowlkes; Ilaria Iacobucci; Kirsten Dickerson; Charles G Mullighan; Peter Vogel; Jerold E Rehg Journal: Vet Pathol Date: 2020-11-19 Impact factor: 2.221