Literature DB >> 2849930

Inhibition of the proteolysis of rat erythrocyte membrane proteins by a synthetic inhibitor of calpain.

S Mehdi1, M R Angelastro, J S Wiseman, P Bey.   

Abstract

A synthetic inhibitor of calpain protects rat erythrocyte membrane-associated cytoskeletal proteins from proteolytic degradation (IC50 = 1 microM) which occurs when the cells are rendered permeable to Ca++. Leupeptin, a naturally occurring inhibitor of the enzyme, does not afford any protection at concentrations up to 100 microM.

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Year:  1988        PMID： 2849930     DOI： 10.1016/s0006-291x(88)80989-6

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  25 in total

1.  Calpain regulates enterocyte brush border actin assembly and pathogenic Escherichia coli-mediated effacement.

Authors:  David A Potter; Anjaiah Srirangam; Kerry A Fiacco; Daniel Brocks; John Hawes; Carter Herndon; Masatoshi Maki; David Acheson; Ira M Herman
Journal:  J Biol Chem       Date:  2003-05-22       Impact factor: 5.157

2.  Relationship of eukaryotic initiation factor 3 to poliovirus-induced p220 cleavage activity.

Authors:  E E Wyckoff; R E Lloyd; E Ehrenfeld
Journal:  J Virol       Date:  1992-05       Impact factor: 5.103

3.  A pharmacological analysis of the neuroprotective efficacy of the brain- and cell-permeable calpain inhibitor MDL-28170 in the mouse controlled cortical impact traumatic brain injury model.

Authors:  Stephanie N Thompson; Kimberly M Carrico; Ayman G Mustafa; Mona Bains; Edward D Hall
Journal:  J Neurotrauma       Date:  2010-12       Impact factor: 5.269

4.  Neuroprotection with delayed calpain inhibition after transient forebrain ischemia.

Authors:  James R Frederick; Zhaoming Chen; Matthew B Bevers; Lori P Ingleton; Marek Ma; Robert W Neumar
Journal:  Crit Care Med       Date:  2008-11       Impact factor: 7.598

Review 5.  Cellular mechanisms of beta-amyloid production and secretion.

Authors:  S Sinha; I Lieberburg
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-28       Impact factor: 11.205

6.  Action of calpastatin in prevention of cardiac L-type Ca2+ channel run-down cannot be mimicked by synthetic calpain inhibitors.

Authors:  K Seydl; J O Karlsson; A Dominik; H Gruber; C Romanin
Journal:  Pflugers Arch       Date:  1995-02       Impact factor: 3.657

7.  Identification and optimization of a novel inhibitor of mitochondrial calpain 10.

Authors:  Kyle A Rasbach; David D Arrington; Sina Odejinmi; Chris Giguere; Craig C Beeson; Rick G Schnellmann
Journal:  J Med Chem       Date:  2009-01-08       Impact factor: 7.446

8.  Comparative behaviour of calpain and cathepsin B toward peptidyl acyloxymethyl ketones, sulphonium methyl ketones and other potential inhibitors of cysteine proteinases.

Authors:  D H Pliura; B J Bonaventura; R A Smith; P J Coles; A Krantz
Journal:  Biochem J       Date:  1992-12-15       Impact factor: 3.857

9.  Synthetic analogues of chymostatin. Inhibition of chymotrypsin and Streptomyces griseus proteinase A.

Authors:  N P Tomkinson; I J Galpin; R J Beynon
Journal:  Biochem J       Date:  1992-09-01       Impact factor: 3.857

10.  Mitochondrial micro-calpain is not involved in the processing of apoptosis-inducing factor.

Authors:  Aashish Joshi; Vimala Bondada; James W Geddes
Journal:  Exp Neurol       Date:  2009-04-23       Impact factor: 5.330
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