Literature DB >> 28498998

Mechanism of Human Influenza Virus RNA Persistence and Virion Survival in Feces: Mucus Protects Virions From Acid and Digestive Juices.

Ryohei Hirose1,2, Takaaki Nakaya2, Yuji Naito1, Tomo Daidoji2, Yohei Watanabe2, Hiroaki Yasuda1, Hideyuki Konishi1, Yoshito Itoh1.   

Abstract

Although viral RNA or infectious virions have been detected in the feces of individuals infected with human influenza A and B viruses (IAV/IBV), the mechanism of viral survival in the gastrointestinal tract remains unclear. We developed a model that attempts to recapitulate the conditions encountered by a swallowed virus. While IAV/IBV are vulnerable to simulated digestive juices (gastric acid and bile/pancreatic juice), highly viscous mucus protects viral RNA and virions, allowing the virus to retain its infectivity. Our results suggest that virions and RNA present in swallowed mucus are not inactivated or degraded by the gastrointestinal environment, allowing their detection in feces.
© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  Influenza; feces; inactivation; mucus; viscosity

Mesh：

Substances：

Year:  2017        PMID： 28498998     DOI： 10.1093/infdis/jix224

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  19 in total

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Authors:  Ryohei Hirose; Takaaki Nakaya; Yuji Naito; Tomo Daidoji; Yohei Watanabe; Hiroaki Yasuda; Hideyuki Konishi; Yoshito Itoh
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Review 10.  Shedding of SARS-CoV-2 in feces and urine and its potential role in person-to-person transmission and the environment-based spread of COVID-19.

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