| Literature DB >> 28497835 |
Rodolphe Beaud1, Raj Kumar Nandi, Alejandro Perez-Luna, Régis Guillot, Didier Gori, Cyrille Kouklovsky, Nour-Eddine Ghermani, Vincent Gandon, Guillaume Vincent.
Abstract
Herein, we report a mechanistic exploration of the unusual FeCl3-mediated hydroarylation of N-Ac indoles. Electron density topology analysis of a crystal, in situ IR monitoring, Hammett and Taft studies as well as DFT computations allowed us to determine that activation of acetyl with FeCl3 and of the C2[double bond, length as m-dash]C3 bond with a proton is involved.Entities:
Year: 2017 PMID： 28497835 DOI： 10.1039/c7cc02756g
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222