| Literature DB >> 28497472 |
Sjors A Koppes1,2, Kristiane A Engebretsen3, Tove Agner4, Irena Angelova-Fischer5, Teresa Berents6,7, Johanna Brandner8, Richard Brans9, Maja-Lisa Clausen4, Edith Hummler10, Ivone Jakasa11, Ružica Jurakić-Tončic12, Swen M John9, Denis Khnykin13,14, Sonja Molin15, Jan O Holm6,7, Sari Suomela16, Hermann-Josef Thierse17,18, Sanja Kezic1, Stefan F Martin19, Jacob P Thyssen3.
Abstract
Contact sensitization is common and affects up to 20% of the general population. The clinical manifestation of contact sensitization is allergic contact dermatitis. This is a clinical expression that is sometimes difficult to distinguish from other types of dermatitis, for example irritant and atopic dermatitis. Several studies have examined the pathogenesis and severity of allergic contact dermatitis by measuring the absence or presence of various biomarkers. In this review, we provide a non-systematic overview of biomarkers that have been studied in allergic contact dermatitis. These include genetic variations and mutations, inflammatory mediators, alarmins, proteases, immunoproteomics, lipids, natural moisturizing factors, tight junctions, and antimicrobial peptides. We conclude that, despite the enormous amount of data, convincing specific biomarkers for allergic contact dermatitis are yet to be described.Entities:
Keywords: allergic contact dermatitis; biomarkers; contact allergy; contact sensitization
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Year: 2017 PMID： 28497472 DOI： 10.1111/cod.12789
Source DB: PubMed Journal: Contact Dermatitis ISSN： 0105-1873 Impact factor: 6.600