Gordon Fisher1, Samuel T Windham2, Perry Griffin3, Jonathan L Warren4, Barbara A Gower4, Gary R Hunter3. 1. Departments of Human Studies, University of Alabama at Birmingham, Birmingham, USA. grdnfs@uab.edu. 2. Department of Surgery, University of Alabama at Birmingham, Birmingham, USA. 3. Departments of Human Studies, University of Alabama at Birmingham, Birmingham, USA. 4. Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, USA.
Abstract
PURPOSE: Cardiometabolic disease remains a leading cause of morbidity and mortality in developed nations. Consequently, identifying and understanding factors associated with underlying pathophysiological processes leading to chronic cardio metabolic conditions is critical. Metabolic health, arterial elasticity, and insulin sensitivity (SI) may impact disease risk, and may be determined in part by myofiber type. Therefore, the purpose of this study was to test the hypothesis that type I myofiber composition would be associated with high SI, greater arterial elasticity, lower blood pressure, and blood lipids; whereas, type IIx myofibers would be associated with lower SI, lower arterial elasticity, higher blood pressure, blood lipids. METHODS: Muscle biopsies were performed on the vastus lateralis in 16 subjects (BMI = 27.62 ± 4.71 kg/m2, age = 32.24 ± 6.37 years, 43% African American). The distribution of type I, IIa, and IIx myofibers was determined via immunohistochemistry performed on frozen cross-sections. Pearson correlation analyses were performed to assess associations between myofiber composition, SI, arterial elasticity, blood pressure, and blood lipid concentrations. RESULTS: The percentage of type I myofibers positively correlated with SI and negatively correlated with systolic blood pressure SBP, diastolic blood pressure, and mean arterial pressure (MAP); whereas, the percentage of type IIx myofibers were negatively correlated with SI and large artery elasticity, and positively correlated with LDL cholesterol, SBP, and MAP. CONCLUSIONS: These data demonstrate a potential link between myofiber composition and cardiometabolic health outcomes in a cohort of premenopausal women. Future research is needed to determine the precise mechanisms in which myofiber composition impacts the pathophysiology of impaired glucose and lipid metabolism, as well as vascular dysfunction.
PURPOSE:Cardiometabolic disease remains a leading cause of morbidity and mortality in developed nations. Consequently, identifying and understanding factors associated with underlying pathophysiological processes leading to chronic cardio metabolic conditions is critical. Metabolic health, arterial elasticity, and insulin sensitivity (SI) may impact disease risk, and may be determined in part by myofiber type. Therefore, the purpose of this study was to test the hypothesis that type I myofiber composition would be associated with high SI, greater arterial elasticity, lower blood pressure, and blood lipids; whereas, type IIx myofibers would be associated with lower SI, lower arterial elasticity, higher blood pressure, blood lipids. METHODS: Muscle biopsies were performed on the vastus lateralis in 16 subjects (BMI = 27.62 ± 4.71 kg/m2, age = 32.24 ± 6.37 years, 43% African American). The distribution of type I, IIa, and IIx myofibers was determined via immunohistochemistry performed on frozen cross-sections. Pearson correlation analyses were performed to assess associations between myofiber composition, SI, arterial elasticity, blood pressure, and blood lipid concentrations. RESULTS: The percentage of type I myofibers positively correlated with SI and negatively correlated with systolic blood pressure SBP, diastolic blood pressure, and mean arterial pressure (MAP); whereas, the percentage of type IIx myofibers were negatively correlated with SI and large artery elasticity, and positively correlated with LDL cholesterol, SBP, and MAP. CONCLUSIONS: These data demonstrate a potential link between myofiber composition and cardiometabolic health outcomes in a cohort of premenopausal women. Future research is needed to determine the precise mechanisms in which myofiber composition impacts the pathophysiology of impaired glucose and lipid metabolism, as well as vascular dysfunction.
Authors: M Harold Laughlin; Jaume Padilla; Nathan T Jenkins; Pamela K Thorne; Jeffrey S Martin; R Scott Rector; Sadia Akter; J Wade Davis Journal: J Appl Physiol (1985) Date: 2015-07-16
Authors: Marcas M Bamman; Ronald C Ragan; Jeong-Su Kim; James M Cross; Vernishia J Hill; S Craig Tuggle; Richard M Allman Journal: J Appl Physiol (1985) Date: 2004-05-21
Authors: Jeannie Tay; Amy M Goss; W Timothy Garvey; Mark E Lockhart; Nikki C Bush; Michael J Quon; Gordon Fisher; Barbara A Gower Journal: Am J Clin Nutr Date: 2020-03-01 Impact factor: 7.045
Authors: Gary R Hunter; Gordon Fisher; David R Bryan; Juliano H Borges; Stephen J Carter Journal: J Strength Cond Res Date: 2018-11 Impact factor: 3.775
Authors: Filip Jevtovic; Polina M Krassovskaia; Christian A Lopez; Kelsey H Fisher-Wellman; Ronald N Cortright; Nicholas T Broskey Journal: Biomedicines Date: 2022-06-20
Authors: Thibault Besson; Robin Macchi; Jeremy Rossi; Cédric Y M Morio; Yoko Kunimasa; Caroline Nicol; Fabrice Vercruyssen; Guillaume Y Millet Journal: Sports Med Date: 2022-02-05 Impact factor: 11.928