Literature DB >> 28496591

Underutilization of Warfarin Therapy in Elderly Patients with Atrial Fibrillation - Fear or False Sense of Security!

Mazda Biria1,2, Ahmad Batrash1, Jayasree Piallarisetti2, James Vacek2, Loren Berenbom2, Dhanunjaya Lakkireddy2.   

Abstract

Background: Under utilization of warfarin in elderly patients with atrial fibrillation (AF) has been recognized as a significant health care issue. This study examines the rate and reasons for warfarin underutilization in elderly patients with AF at the Kansas City Veterans Affairs Medical Center.
Methods: Retrospective study reviewing electronic medical records of all patients aged 65 and older with the diagnosis of atrial fibrillation. Patients on warfarin were excluded. Reasons for not using warfarin were extracted by reviewing the electronic medical record. Anticoagulation indications for these patients were determined based on the ACC/AHA/ESC 2006 Guidelines for the Management of Patients with Atrial Fibrillation.
Results: Warfarin was not used by 407 patients (25%) with known AF. Average age was 79+6.2 years. 60% of patients had persistent or permanent AF. Prevalence of risk factors for thromboembolism included hypertension (74%), heart failure or ejection fraction of <40% (21%), diabetes (27%) and coronary artery disease (48%). CHADS (2) scores were documented in the charts less than 1% of the times. Only 11 patients had CHADS (2) score of 0 and 70 had a score of 1. A class I or IIa indication for warfarin therapy was present in 298 (73%) of patients. Return to sinus rhythm (37%) was the most common reason for not using warfarin. In 30% of cases the reason not to use warfarin was not addressed. Other reasons not to use warfarin included fear of falls (7%), prior head or GI bleed (14%), patient refusal &amp; noncompliance (12%). History of CVA or TIA was documented in 12% of patients. Conclusions: Underutilization of warfarin in elderly patients with atrial fibrillation remains a common problem despite their high risk for thromboembolic events. A false sense of security about the paroxysmal nature of AF, lack of proper insight about stroke risk (CHADS (2)), and fear of bleeding are the most common reasons for non use of warfarin.

Entities:  

Year:  2008        PMID: 28496591      PMCID: PMC4956376          DOI: 10.4022/jafib.119

Source DB:  PubMed          Journal:  J Atr Fibrillation        ISSN: 1941-6911


  36 in total

1.  Stroke prevention in patients with atrial fibrillation.

Authors:  Ayumu Ono; Toshiro Fujita
Journal:  J Clin Neurosci       Date:  2003-01       Impact factor: 1.961

Review 2.  Atrial fibrillation and stroke: new ideas, persisting dilemmas.

Authors:  J L Halperin; R G Hart
Journal:  Stroke       Date:  1988-08       Impact factor: 7.914

3.  Efficacy of anticoagulation for secondary stroke prevention in older people with non-valvular atrial fibrillation: a prospective case series study.

Authors:  Georgios Tsivgoulis; Konstantinos Spengos; Nikolaos Zakopoulos; Efstathios Manios; Vassilios Peppes; Konstantinos Vemmos
Journal:  Age Ageing       Date:  2005-01       Impact factor: 10.668

4.  Atrial fibrillation and stroke in the general medicare population: a 10-year perspective (1992 to 2002).

Authors:  Kamakshi Lakshminarayan; Craig A Solid; Allan J Collins; David C Anderson; Charles A Herzog
Journal:  Stroke       Date:  2006-06-29       Impact factor: 7.914

5.  Atrial fibrillation is associated with severe acute ischemic stroke.

Authors:  Douglas A Dulli; Heather Stanko; Ross L Levine
Journal:  Neuroepidemiology       Date:  2003 Mar-Apr       Impact factor: 3.282

6.  Incidence of intracranial hemorrhage in patients with atrial fibrillation who are prone to fall.

Authors:  Brian F Gage; Elena Birman-Deych; Roger Kerzner; Martha J Radford; David S Nilasena; Michael W Rich
Journal:  Am J Med       Date:  2005-06       Impact factor: 4.965

7.  Warfarin maintenance dosages in the very elderly.

Authors:  Dana L Singla; Gregory B Morrill
Journal:  Am J Health Syst Pharm       Date:  2005-05-15       Impact factor: 2.637

8.  Factors influencing physicians' reported use of anticoagulation therapy in nonvalvular atrial fibrillation: a cross-sectional survey.

Authors:  Cary P Gross; Eric W Vogel; Abhay J Dhond; Cheryl B Marple; Roger A Edwards; Ole Hauch; Elizabeth A Demers; Michael Ezekowitz
Journal:  Clin Ther       Date:  2003-06       Impact factor: 3.393

9.  Thromboembolic prophylaxis in nonrheumatic atrial fibrillation: utilization patterns, efficacy, and complications in a long-term follow-up of community patients.

Authors:  Miry Blich; Bella Gross
Journal:  Int J Cardiol       Date:  2004-07       Impact factor: 4.164

10.  Stroke prevention in hospitalized patients with atrial fibrillation: a population-based study.

Authors:  Seema Nagpal; David Anderson; Wayne Putnam; Gordon Flowerdew; Martin Gardner; Jafna Cox
Journal:  Can J Clin Pharmacol       Date:  2003
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