Literature DB >> 28496538

Iron Pill Gastritis: An Under Diagnosed Condition With Potentially Serious Outcomes.

Tagore Sunkara1, Megan E Caughey2, Sofia Nigar1, Raquel Olivo3, Vinaya Gaduputi3.   

Abstract

Given the ubiquitous use of oral iron therapy, their side effects are often encountered and well recognized in clinical practice. However, iron pill gastritis remains an often under-reported and elusive diagnosis. An astute clinician should be aware of this condition in order to promptly discontinue oral iron and institute timely treatment. Here in, we present a case of a 46-year-old woman who presented to the gastroenterology clinic with vague epigastric pain and microcytic anemia. Esophagogastroduodenoscopy revealed multiple gastric erosions and non-bleeding gastric antral ulcer with biopsies showing excessive iron deposition suggestive of iron pill gastritis. We reviewed the clinical features, pathology, and treatment of iron pill gastritis along with the review of the literature.

Entities:  

Keywords:  Anemia; Ferrous sulfate; Gastric ulcer; Gastritis; Iron pill gastritis; Iron sulfate; Oral iron supplementation

Year:  2017        PMID: 28496538      PMCID: PMC5412550          DOI: 10.14740/gr804w

Source DB:  PubMed          Journal:  Gastroenterology Res        ISSN: 1918-2805


  7 in total

1.  Iron-induced mucosal injury to the upper gastrointestinal tract.

Authors:  A Haig; D K Driman
Journal:  Histopathology       Date:  2006-06       Impact factor: 5.087

2.  Iron pill-induced tumefactive mucosal injury of the hypopharynx.

Authors:  Ashley Cimino-Mathews; Jerry H Broman; William H Westra; Peter B Illei
Journal:  Am J Surg Pathol       Date:  2010-11       Impact factor: 6.394

3.  Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Are lactoferrin and transferrin promoters of hydroxyl-radical generation?

Authors:  O I Aruoma; B Halliwell
Journal:  Biochem J       Date:  1987-01-01       Impact factor: 3.857

4.  Erosive injury to the upper gastrointestinal tract in patients receiving iron medication: an underrecognized entity.

Authors:  S C Abraham; J H Yardley; T T Wu
Journal:  Am J Surg Pathol       Date:  1999-10       Impact factor: 6.394

5.  Iron-induced mucosal pathology of the upper gastrointestinal tract: a common finding in patients on oral iron therapy.

Authors:  P Kaye; K Abdulla; J Wood; P James; S Foley; K Ragunath; J Atherton
Journal:  Histopathology       Date:  2008-09       Impact factor: 5.087

6.  Iron Pill-Induced Gastritis.

Authors:  Jana G Hashash; Siobhan Proksell; Shih-Fan Kuan; Jaideep Behari
Journal:  ACG Case Rep J       Date:  2013-10-08

Review 7.  Gastric siderosis: An under-recognized and rare clinical entity.

Authors:  Jiten P Kothadia; Rezina Arju; Monica Kaminski; Arif Mahmud; Jonathan Chow; Shah Giashuddin
Journal:  SAGE Open Med       Date:  2016-02-19
  7 in total
  3 in total

1.  Iron Overload in Gastric Mucosa: Underdiagnosed Condition Rarely Documented in Clinical and Pathology Reports.

Authors:  Monica Onorati; Marta Nicola; Anna Renda; Mauro Lancia; Franca Di Nuovo
Journal:  Cureus       Date:  2020-05-22

Review 2.  "Stranger things" in the gut: uncommon items in gastrointestinal specimens.

Authors:  Federica Grillo; Michela Campora; Luca Carlin; Laura Cornara; Paola Parente; Alessandro Vanoli; Andrea Remo; Paola Migliora; Fiocca Roberto; Matteo Fassan; Luca Mastracci
Journal:  Virchows Arch       Date:  2021-10-01       Impact factor: 4.064

3.  Zinc Acetate Dihydrate Tablet-associated Gastric Lesions.

Authors:  Masaya Iwamuro; Takehiro Tanaka; Sakiko Kuraoka; Kenta Hamada; Makoto Abe; Yoshiyasu Kono; Hiromitsu Kanzaki; Seiji Kawano; Yoshiro Kawahara; Hiroyuki Okada
Journal:  Intern Med       Date:  2022-07-01       Impact factor: 1.282

  3 in total

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