Literature DB >> 28495308

Pharmaceutical prospects of naturally occurring quinazolinone and its derivatives.

Dan He1, Menglei Wang1, Siyu Zhao1, Yisong Shu1, Honglian Zeng1, Cheng Xiao2, Cheng Lu3, Yuanyan Liu4.   

Abstract

Quinazolinones belong to a family of heterocyclic nitrogen compounds that have attracted increasing interest because of their broad spectrum of biological functions. This review describes three types of natural quinazolinones and their synthesized derivatives and summarizes their various pharmacological activities, including antifungal, anti-tumor, anti-malaria, anticonvulsant, anti-microbial, anti-inflammatory and antihyperlipidemic activities. In addition, structure-activity relationships of quinazolinone derivatives are also reviewed.
Copyright © 2017 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Chemical structures; Pharmaceutical activities; Quinazolinones; Structure-activity relationship

Mesh：

Substances：

Year:  2017        PMID： 28495308     DOI： 10.1016/j.fitote.2017.05.001

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  8 in total

1.  Synthesis of benzo[4,5]imidazo[1,2-a]pyrimidines and 2,3-dihydroquinazolin-4(1H)-ones under metal-free and solvent-free conditions for minimizing waste generation.

Authors:  Phuong Hoang Tran; Thanh-Phuong Thi Bui; Xuan-Quynh Bach Lam; Xuan-Trang Thi Nguyen
Journal:  RSC Adv       Date:  2018-10-26       Impact factor: 4.036

2.  Discovery of novel glycerolated quinazolinones from Streptomyces sp. MBT27.

Authors:  Nataliia V Machushynets; Changsheng Wu; Somayah S Elsayed; Thomas Hankemeier; Gilles P van Wezel
Journal:  J Ind Microbiol Biotechnol       Date:  2019-02-07       Impact factor: 3.346

3.  Synthesis, Antiproliferative, and Antioxidant Evaluation of 2-Pentylquinazolin-4(3H)-one(thione) Derivatives with DFT Study.

Authors:  Amira A El-Sayed; Mahmoud F Ismail; Abd El-Galil E Amr; Ahmed M Naglah
Journal:  Molecules       Date:  2019-10-21       Impact factor: 4.411

4.  Untargeted liquid chromatography coupled with mass spectrometry reveals metabolic changes in nitrogen-deficient Isatis indigotica Fortune.

Authors:  Yi-Wen Cao; Ren-Jun Qu; Yu-Jing Miao; Xiao-Qing Tang; Ying Zhou; Lei Wang; Li Geng
Journal:  Phytochemistry       Date:  2019-07-04       Impact factor: 4.072

5.  A novel superparamagnetic powerful guanidine-functionalized γ-Fe2O3 based sulfonic acid recyclable and efficient heterogeneous catalyst for microwave-assisted rapid synthesis of quinazolin-4(3H)-one derivatives in Green media.

Authors:  Fateme Haji Norouzi; Naser Foroughifar; Alireza Khajeh-Amiri; Hoda Pasdar
Journal:  RSC Adv       Date:  2021-09-07       Impact factor: 3.361

6.  Synthesis, antitumor activity, 3D-QSAR and molecular docking studies of new iodinated 4-(3H)-quinazolinones 3N-substituted.

Authors:  Marcia Pérez-Fehrmann; Víctor Kesternich; Arturo Puelles; Víctor Quezada; Fernanda Salazar; Philippe Christen; Jonathan Castillo; Juan Guillermo Cárcamo; Alejandro Castro-Alvarez; Ronald Nelson
Journal:  RSC Adv       Date:  2022-08-02       Impact factor: 4.036

7.  Synthesis of a Pyrrolo[1,2-a]quinazoline-1,5-dione Derivative by Mechanochemical Double Cyclocondensation Cascade.

Authors:  Vanessza Judit Kolcsár; György Szőllősi
Journal:  Molecules       Date:  2022-09-02       Impact factor: 4.927

Review 8.  Review of Oxepine-Pyrimidinone-Ketopiperazine Type Nonribosomal Peptides.

Authors:  Yaojie Guo; Jens C Frisvad; Thomas O Larsen
Journal:  Metabolites       Date:  2020-06-15
  8 in total

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