Hui-Jie Qiao1, Zhen-Zhi Li1, Li-Ming Wang1, Wei Sun1, Jin-Chao Yu1, Bin Wang2. 1. Department of Radiology, Weihai Municipal Hospital, Binzhou Medical University, Weihai, China. 2. Medical Imaging Research Institute, Binzhou Medical University, Yantai, China. Electronic address: Zluoybsh@126.com.
Abstract
OBJECTIVE: Brain-derived neurotrophic factor (BDNF) plays a potential role in stroke recovery, as it promotes plasticity. The aim of this study is to investigate the association between infarct volume using DWI and BDNF at admission in patients with acute ischemic stroke (AIS). METHODS: The study population comprised consecutive patients with an AIS diagnosis who had been referred to our hospital between January 2015 and June 2016. The severity of stroke was evaluated by the National Institutes of Health Stroke Scale (NIHSS) at admission. Infarct volumes indicated by DWI were measured with MIPAV software. The relationship between median DWI infarct volume and serum BDNF level quartiles was evaluated using a semiparametric approach with univariate and multivariate quartile regression analysis. RESULTS: In this study, 270 patients were included and met the study criteria. The median DWI infarct volumes for the serum BDNF level quartiles (lowest to highest) were 10.56, 5.13, 3.75 and 2.43ml. Nonparametric Spearman rank correlation revealed a statistically significant negative correlation between serum BDNF level and DWI infarct volume (r=-0.363; P<0.001). The median DWI infarct volume in the lowest BDNF quartile was significantly larger than those in the upper 3 quartiles (P<0.001). Further, median adjusted DWI infarct volumes (IQR) for each of the BDNF level quartiles were 7.77, 4.56, 3.75, and 2.43ml from lowest to highest quartiles. CONCLUSIONS: Larger stroke infarct volumes using DWI are associated with lower levels of BDNF at admission. Further investigations are suggested to elucidate the role of BDNF as part of a potential neuroprotective strategy.
OBJECTIVE:Brain-derived neurotrophic factor (BDNF) plays a potential role in stroke recovery, as it promotes plasticity. The aim of this study is to investigate the association between infarct volume using DWI and BDNF at admission in patients with acute ischemic stroke (AIS). METHODS: The study population comprised consecutive patients with an AIS diagnosis who had been referred to our hospital between January 2015 and June 2016. The severity of stroke was evaluated by the National Institutes of Health Stroke Scale (NIHSS) at admission. Infarct volumes indicated by DWI were measured with MIPAV software. The relationship between median DWI infarct volume and serum BDNF level quartiles was evaluated using a semiparametric approach with univariate and multivariate quartile regression analysis. RESULTS: In this study, 270 patients were included and met the study criteria. The median DWI infarct volumes for the serum BDNF level quartiles (lowest to highest) were 10.56, 5.13, 3.75 and 2.43ml. Nonparametric Spearman rank correlation revealed a statistically significant negative correlation between serum BDNF level and DWI infarct volume (r=-0.363; P<0.001). The median DWI infarct volume in the lowest BDNF quartile was significantly larger than those in the upper 3 quartiles (P<0.001). Further, median adjusted DWI infarct volumes (IQR) for each of the BDNF level quartiles were 7.77, 4.56, 3.75, and 2.43ml from lowest to highest quartiles. CONCLUSIONS: Larger stroke infarct volumes using DWI are associated with lower levels of BDNF at admission. Further investigations are suggested to elucidate the role of BDNF as part of a potential neuroprotective strategy.
Authors: Tomás Sobrino; Manuel Rodríguez-Yáñez; Francisco Campos; Ramón Iglesias-Rey; Mónica Millán; Natalia Pérez de la Ossa; Antonio Dávalos; Raquel Delgado-Mederos; Alejandro Martínez-Domeño; Joan Martí-Fábregas; Mar Castellanos; Joaquín Serena; Aida Lago; Exuperio Díez-Tejedor; José Castillo Journal: Transl Stroke Res Date: 2019-11-25 Impact factor: 6.829
Authors: Natalia Cichoń; Michał Bijak; Piotr Czarny; Elżbieta Miller; Ewelina Synowiec; Tomasz Sliwinski; Joanna Saluk-Bijak Journal: Front Aging Neurosci Date: 2018-09-26 Impact factor: 5.750