Uttam K Raheja1, Dietmar Fuchs2, Christopher A Lowry3, Sarah H Stephens4, Mary A Pavlovich4, Hira Mohyuddin5, Hassaan Yousufi5, Kathleen A Ryan4, Jeff O'Connell4, Lisa A Brenner6, Cecile Punzalan7, Andrew J Hoisington8, Gursharon K Nijjar5, Maureen Groer9, Alan R Shuldiner4, Toni I Pollin4, John W Stiller10, Braxton D Mitchell11, Teodor T Postolache12. 1. Mood and Anxiety Program, University of Maryland School of Medicine, 685 W. Baltimore Street, Suite# 930, Baltimore, MD 21201, USA; Child and Adolescent Psychiatry Residency Program, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Drive, Atlanta, GA 30329, USA. 2. Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innrain 80, 6020, Innsbruck, Austria. 3. Rocky Mountain Mental Illness Research Education and Clinical Center (MIRECC), Veterans Integrated Service Network (VISN) 19, 1055 Clermont St, Denver, CO 80220, USA; Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, 13001 E 17th Pl, Aurora, CO 80045, USA; Military and Veteran Microbiome Consortium for Research and Education (MVM-CoRE), 1055 Clermont St, Denver, CO 80220, USA; Department of Integrative Physiology and Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309, USA; Center for Neuroscience, University of Colorado Anschutz Medical Campus, 13001 E 17th Pl, Aurora, CO 80045, USA. 4. Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, 685 W. Baltimore Street, Baltimore, MD 21201, USA; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, 685 W. Baltimore Street, Baltimore, MD 21201, USA. 5. Mood and Anxiety Program, University of Maryland School of Medicine, 685 W. Baltimore Street, Suite# 930, Baltimore, MD 21201, USA. 6. Rocky Mountain Mental Illness Research Education and Clinical Center (MIRECC), Veterans Integrated Service Network (VISN) 19, 1055 Clermont St, Denver, CO 80220, USA; Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, 13001 E 17th Pl, Aurora, CO 80045, USA; Military and Veteran Microbiome Consortium for Research and Education (MVM-CoRE), 1055 Clermont St, Denver, CO 80220, USA. 7. U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition Office of Analytics and Outreach, Division of Public Health Informatics and Analytics, 5001 Campus Drive, College Park, MD 20740, USA. 8. Military and Veteran Microbiome Consortium for Research and Education (MVM-CoRE), 1055 Clermont St, Denver, CO 80220, USA; Department of Civil and Environmental Engineering, US Air Force Academy, Colorado Springs, CO 80840, USA. 9. College of Nursing, University of South Florida, 4202 E Fowler Ave, Tampa, FL 33620, USA. 10. Mood and Anxiety Program, University of Maryland School of Medicine, 685 W. Baltimore Street, Suite# 930, Baltimore, MD 21201, USA; Department of Behavioral Health, St. Elizabeth's Hospital, 1100 Alabama Ave SE, Washington, DC 20032, USA. 11. Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, 685 W. Baltimore Street, Baltimore, MD 21201, USA; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, 685 W. Baltimore Street, Baltimore, MD 21201, USA; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD 20201, USA. 12. Mood and Anxiety Program, University of Maryland School of Medicine, 685 W. Baltimore Street, Suite# 930, Baltimore, MD 21201, USA; Rocky Mountain Mental Illness Research Education and Clinical Center (MIRECC), Veterans Integrated Service Network (VISN) 19, 1055 Clermont St, Denver, CO 80220, USA; Military and Veteran Microbiome Consortium for Research and Education (MVM-CoRE), 1055 Clermont St, Denver, CO 80220, USA; Mental Illness Research, Education and Clinical Center (MIRECC), Veterans Integrated Service Network (VISN) 5, VA Capitol Health Care Network, 209 West Fayette Street, Baltimore, MD 21201, USA. Electronic address: tpostola@som.umaryland.edu.
Abstract
BACKGROUND: We examined the heritability of neopterin, a biomarker for cell-mediated immunity and oxidative stress, and potentially for psychiatric disorders, in the Old Order Amish. METHODS: Plasma neopterin levels were determined in 2015 Old Order Amish adults. Quantitative genetic procedures were used to estimate heritability of neopterin. RESULTS: Heritability of log-neopterin was estimated at 0.07 after adjusting for age, gender, and household (p=0.03). The shared household effect was 0.06 (p<0.02). CONCLUSIONS: We found a low heritability of neopterin and small household effect, suggesting that non-household environmental factors are more important determinants of variance of neopterin levels in the Amish.
BACKGROUND: We examined the heritability of neopterin, a biomarker for cell-mediated immunity and oxidative stress, and potentially for psychiatric disorders, in the Old Order Amish. METHODS: Plasma neopterin levels were determined in 2015 Old Order Amish adults. Quantitative genetic procedures were used to estimate heritability of neopterin. RESULTS: Heritability of log-neopterin was estimated at 0.07 after adjusting for age, gender, and household (p=0.03). The shared household effect was 0.06 (p<0.02). CONCLUSIONS: We found a low heritability of neopterin and small household effect, suggesting that non-household environmental factors are more important determinants of variance of neopterin levels in the Amish.
Authors: Hira Mohyuddin; Polymnia Georgiou; Abhishek Wadhawan; Melanie L Daue; Lisa A Brenner; Claudia Gragnoli; Erika F H Saunders; Dietmar Fuchs; Christopher A Lowry; Teodor T Postolache Journal: Pteridines Date: 2017-12-02 Impact factor: 0.581
Authors: Xuesi Wan; James Perry; Haichen Zhang; Feng Jin; Kathleen A Ryan; Cristopher Van Hout; Jeffrey Reid; John Overton; Aris Baras; Zhe Han; Elizabeth Streeten; Yanbing Li; Braxton D Mitchell; Alan R Shuldiner; Mao Fu Journal: J Am Soc Nephrol Date: 2021-02-04 Impact factor: 10.121