Zhen Lu1, Henry Rosenberg2, Guohua Li3. 1. Department of Epidemiology, Columbia University Mailman School of Public Health, 722 West 168(th) St, R1508, New York, NY 10032, USA. Electronic address: katherinezhenlu@gmail.com. 2. Department of Medical Education and Clinical Research, Saint Barnabas Medical Center, 94 Old Short Hills Road, Livingston, NJ 07039, USA. Electronic address: HRosenberg@barnabashealth.org. 3. Department of Epidemiology, Columbia University Mailman School of Public Health, 722 West 168(th) St, R1508, New York, NY 10032, USA; Department of Anesthesiology, Columbia University College of Physicians and Surgeons, 622 West 168(th) St, PH5-505, New York, NY 10032, USA. Electronic address: GL2240@cumc.columbia.edu.
Abstract
STUDY OBJECTIVE: Malignant hyperthermia (MH) is a rare yet potentially fatal pharmacogenetic disorder triggered by exposure to inhalational anesthetics and the depolarizing neuromuscular blocking agent succinylcholine. Epidemiologic data on the geographic variation in MH prevalence is scant. The objective of this study is to examine the prevalence of recorded MH diagnosis in patients discharged from hospitals in four states in the United States. DESIGN: Observational study. SETTING: Healthcare Cost and Utilization Project (HCUP) State Inpatient Database (SID) for California (2011), Florida (2011), New York (2012) and Wisconsin (2012). PATIENTS: A total of 164 hospital discharges that had a recorded diagnosis of MH using the International Classification of Disease, 9th Revision, Clinical Modification code 995.86. METHODS: MH prevalence was assessed by patient demographic and clinical characteristics. MAIN RESULTS: The prevalence of MH per 100,000 hospital discharges ranged from 1.23 (95% Confidence Interval [CI], 0.80-1.66) in New York to 1.91 (95% CI, 1.48-2.34) in California, and the prevalence of MH per 100,000 surgical discharges ranged from 1.47 (95% CI, 0.93-2.02) in New York to 2.86 (95% CI, 2.00-3.71) in Florida. The prevalence of MH in male patients was more than twice the prevalence in female patients. Of the 164 patients with MH diagnosis, 11% were dead on discharge. CONCLUSIONS: There exists a modest variation in the prevalence of recorded MH diagnosis in hospital discharges in California, Florida, New York and Wisconsin. Epidemiologic patterns of MH diagnosis in hospital discharges appear to be similar across the four states. Further research is needed to better understand the geographic variation and contributing factors of MH in different populations.
STUDY OBJECTIVE:Malignant hyperthermia (MH) is a rare yet potentially fatal pharmacogenetic disorder triggered by exposure to inhalational anesthetics and the depolarizing neuromuscular blocking agent succinylcholine. Epidemiologic data on the geographic variation in MH prevalence is scant. The objective of this study is to examine the prevalence of recorded MH diagnosis in patients discharged from hospitals in four states in the United States. DESIGN: Observational study. SETTING: Healthcare Cost and Utilization Project (HCUP) State Inpatient Database (SID) for California (2011), Florida (2011), New York (2012) and Wisconsin (2012). PATIENTS: A total of 164 hospital discharges that had a recorded diagnosis of MH using the International Classification of Disease, 9th Revision, Clinical Modification code 995.86. METHODS: MH prevalence was assessed by patient demographic and clinical characteristics. MAIN RESULTS: The prevalence of MH per 100,000 hospital discharges ranged from 1.23 (95% Confidence Interval [CI], 0.80-1.66) in New York to 1.91 (95% CI, 1.48-2.34) in California, and the prevalence of MH per 100,000 surgical discharges ranged from 1.47 (95% CI, 0.93-2.02) in New York to 2.86 (95% CI, 2.00-3.71) in Florida. The prevalence of MH in male patients was more than twice the prevalence in female patients. Of the 164 patients with MH diagnosis, 11% were dead on discharge. CONCLUSIONS: There exists a modest variation in the prevalence of recorded MH diagnosis in hospital discharges in California, Florida, New York and Wisconsin. Epidemiologic patterns of MH diagnosis in hospital discharges appear to be similar across the four states. Further research is needed to better understand the geographic variation and contributing factors of MH in different populations.
Authors: Bryant W Cornelius; Shelby Olsen Dib; Regina A Dowdy; Christina K Horton; Katherine Frimenko; Shadee Mansour; Farah Abu Sharkh; Marcus T Joy; David L Hall; Hany A Emam; Courtney A Jatana; Kelly S Kennedy Journal: Anesth Prog Date: 2019
Authors: Hui J Wang; Chang Seok Lee; Rachel Sue Zhen Yee; Linda Groom; Inbar Friedman; Lyle Babcock; Dimitra K Georgiou; Jin Hong; Amy D Hanna; Joseph Recio; Jong Min Choi; Ting Chang; Nadia H Agha; Jonathan Romero; Poonam Sarkar; Nicol Voermans; M Waleed Gaber; Sung Yun Jung; Matthew L Baker; Robia G Pautler; Robert T Dirksen; Sheila Riazi; Susan L Hamilton Journal: Nat Commun Date: 2020-10-09 Impact factor: 17.694