Literature DB >> 28494607

SCN9A channelopathy associated autosomal recessive Congenital Indifference to Pain. A case report.

S Rajasekharan1, L Martens1, L Domingues1, R Cauwels1.   

Abstract

BACKGROUND: Congenital Indifference to Pain (CIP) is a rare condition that inhibits the ability of patients to perceive physical pain but otherwise keeps normal sensory modalities. The condition has been mapped to an autosomal recessive trait to chromosome 2q 24.3 with mutations on the SCN9A gene. CASE REPORT: A 2 year old Caucasian female presented with CIP. Bite injuries, tongue wounds and unaccounted dental trauma episodes were frequently reported. Preventive instructions and possible treatment modalities were discussed with the parents.
CONCLUSION: The cornerstone of treating CIP patients is an extensive preventive approach alongside regular oral examination at home by parents as well as routine recall appointments with dentists.

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Year:  2017        PMID: 28494607     DOI: 10.23804/ejpd.2017.18.01.14

Source DB:  PubMed          Journal:  Eur J Paediatr Dent        ISSN: 1591-996X            Impact factor:   2.231


  3 in total

Review 1.  Painful and painless mutations of SCN9A and SCN11A voltage-gated sodium channels.

Authors:  Mark D Baker; Mohammed A Nassar
Journal:  Pflugers Arch       Date:  2020-06-29       Impact factor: 3.657

2.  Introducing Critical Pain-related Genes: A System Biology Approach.

Authors:  Mostafa Rezaei Tavirani; Sina Rezaei Tavirani; Mohammad-Mahdi Zadeh-Esmaeel; Nayeb Ali Ahmadi
Journal:  Basic Clin Neurosci       Date:  2019-07-01

3.  [Pain asymbolia-discovered around 1930 by Paul F. Schilder, almost forgotten today?]

Authors:  Martin Jahn; Holger Steinberg
Journal:  Schmerz       Date:  2020-04       Impact factor: 1.107

  3 in total

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