Literature DB >> 2849437

Molecular cloning of rat phosphoprotein phosphatase 2A beta cDNA and increased expressions of phosphatase 2A alpha and 2A beta in rat liver tumors.

Y Kitagawa1, R Sakai, T Tahira, H Tsuda, N Ito, T Sugimura, M Nagao.   

Abstract

A cDNA clone coding for an isotype of the catalytic subunit of rat phosphoprotein phosphatase 2A was isolated. The deduced amino acid sequence of the clone was different at 8 positions from that of rat phosphatase 2A alpha determined in a previous study. The deduced amino acid sequence of the clone was, however, identical to that of human phosphatase 2A beta and differed only at one position from that of rabbit 2A beta. Thus, the isolated cDNA was identified as a clone coding for rat phosphatase 2A beta. Using a 2A beta specific probe, two kinds of transcripts were detected in rat liver: a major 2.0 kb mRNA transcript and a minor 1.4 kb mRNA transcript. These transcripts were both greatly increased in rat liver tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) regardless of the carcinoma or hyperplastic nodule.

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Year:  1988        PMID： 2849437     DOI： 10.1016/s0006-291x(88)80323-1

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  5 in total

1.  Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha.

Authors:  J Götz; A Probst; E Ehler; B Hemmings; W Kues
Journal:  Proc Natl Acad Sci U S A       Date:  1998-10-13       Impact factor: 11.205

2.  Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain.

Authors:  D Guerini; C B Klee
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

3.  Mapping of the genes for rat protein phosphatase 2A alpha (PP2A1) and 2A beta (PP2A2) to chromosomes 10 and 16, respectively.

Authors:  Y Muramatsu; T Yamada; T Serikawa; K Matsumoto
Journal:  Mamm Genome       Date:  1994-08       Impact factor: 2.957

4.  Identification of binding sites on the regulatory A subunit of protein phosphatase 2A for the catalytic C subunit and for tumor antigens of simian virus 40 and polyomavirus.

Authors:  R Ruediger; D Roeckel; J Fait; A Bergqvist; G Magnusson; G Walter
Journal:  Mol Cell Biol       Date:  1992-11       Impact factor: 4.272

5.  Identification of members of the protein phosphatase 1 gene family in the rat and enhanced expression of protein phosphatase 1 alpha gene in rat hepatocellular carcinomas.

Authors:  K Sasaki; H Shima; Y Kitagawa; S Irino; T Sugimura; M Nagao
Journal:  Jpn J Cancer Res       Date:  1990-12
  5 in total

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